SCHEMBL256571

SCHEMBL256571

COC(c1ccc(F)cc1)c1nc(Nc2cc(C)[nH]n2)c2ccsc2n1

nearest known ligand 0.51

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
JAK2 O60674 6/20 0.51
JAK3 P52333 5/20 0.51
CYP3A4 P08684 3/20 0.51
CYP2C8 P10632 3/20 0.51
CYP2C9 P11712 3/20 0.51
JAK1 P23458 3/20 0.51
TYK2 P29597 3/20 0.51
CYP2C19 P33261 3/20 0.51
ADORA3 P0DMS8 2/20 0.51
CYP1A2 P05177 1/20 0.51
NTRK1 P04629 4/20 0.43
LIMK1 P53667 1/20 0.43
LIMK2 P53671 1/20 0.43
AURKA O14965 6/20 0.43
AURKB Q96GD4 5/20 0.43
PLK4 O00444 1/20 0.41
PAK4 O96013 1/20 0.41
SYK P43405 2/20 0.39
SRC P12931 1/20 0.39
EIF2AK2 P19525 1/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL165150 1.00 JAK2 (0.51) JAK2JAK3CYP3A4CYP2C8CYP2C9
SCHEMBL10232045 0.87 JAK2 (0.53) JAK2JAK3CYP3A4CYP2C8CYP2C9
SCHEMBL174790 0.86 JAK2 (0.68) JAK2JAK3CYP3A4CYP2C8CYP2C9
SCHEMBL166986 0.85 JAK2 (0.52) JAK2JAK3CYP3A4CYP2C8CYP2C9
SCHEMBL186745 0.82 JAK2 (0.74) JAK2JAK3CYP3A4CYP2C8CYP2C9
SCHEMBL10224871 0.82 JAK2 (0.74) JAK2JAK3CYP3A4CYP2C8CYP2C9
SCHEMBL174424 0.82 JAK2 (0.74) JAK2JAK3CYP3A4CYP2C8CYP2C9
SCHEMBL12105318 0.76 JAK2 (0.48) JAK2JAK3CYP3A4CYP2C8CYP2C9
SCHEMBL12102775 0.75 JAK2 (0.52) JAK2JAK3CYP3A4CYP2C8CYP2C9
SCHEMBL174808 0.75 AURKA (0.60) JAK2JAK3CYP3A4CYP2C8CYP2C9

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2611812-A1 THIENOPYRIDINE AND THIENOPYRIMIDINE COMPOUNDS AND METHODS OF USE THEREOF Ambit Biosciences Corporation (US) 2013-07-10 EP disclosed
WO-2012030894-A1 THIENOPYRIDINE AND THIENOPYRIMIDINE COMPOUNDS AND METHODS OF USE THEREOF AMBIT BIOSCIENCES CORPORATION (US) 2012-03-08 WO disclosed
WO-2012030894-A1 THIENOPYRIDINE AND THIENOPYRIMIDINE COMPOUNDS AND METHODS OF USE THEREOF AMBIT BIOSCIENCES CORPORATION (US) 2012-03-08 WO disclosed