SCHEMBL2565732 — predicted protein targets

Predicted protein targets (top 15)

	gene	UniProt	supporting neighbours	confidence
▸	JAK2	O60674	4/20	0.53

▸	JAK3	P52333	4/20	0.53

▸	LIMK1	P53667	1/20	0.53

▸	LIMK2	P53671	1/20	0.53

▸	NTRK1	P04629	9/20	0.48

▸	GRK6	P43250	7/20	0.43

▸	AURKA	O14965	2/20	0.43

▸	MUSK	O15146	1/20	0.40

▸	LCK	P06239	1/20	0.40

▸	RET	P07949	1/20	0.40

▸	FGFR3	P22607	1/20	0.40

▸	CCNE1	P24864	1/20	0.40

▸	CDK2	P24941	1/20	0.40

▸	FLT3	P36888	1/20	0.40

▸	PTK2B	Q14289	1/20	0.40

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compound	similarity	top predicted	shared targets
SCHEMBL2565727	1.00	JAK2 (0.53)	JAK2JAK3LIMK1LIMK2NTRK1
SCHEMBL2561629	0.89	JAK2 (0.42)	JAK2JAK3LIMK1LIMK2NTRK1
SCHEMBL2561614	0.89	JAK2 (0.42)	JAK2JAK3LIMK1LIMK2NTRK1
SCHEMBL2578945	0.86	JAK2 (0.51)	JAK2JAK3LIMK1LIMK2NTRK1
SCHEMBL2567182	0.86	NTRK1 (0.57)	JAK2JAK3LIMK1LIMK2NTRK1
SCHEMBL2578947	0.86	JAK2 (0.51)	JAK2JAK3LIMK1LIMK2NTRK1
SCHEMBL2567176	0.86	NTRK1 (0.57)	JAK2JAK3LIMK1LIMK2NTRK1
SCHEMBL2486709	0.84	JAK3 (0.75)	JAK2JAK3LIMK1LIMK2NTRK1
SCHEMBL2486710	0.84	JAK3 (0.75)	JAK2JAK3LIMK1LIMK2NTRK1
SCHEMBL2577239	0.83	JAK2 (0.52)	JAK2JAK3LIMK1LIMK2NTRK1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

Patent	Title	Assignee	Published	Priority	Filing	Country	Status
EP-2383268-A1	Pyrazolylaminopyridine derivatives useful as kinase inhibitors	AstraZeneca AB (SE)	2011-11-02	—	—	EP	disclosed