Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC3 | O15379 | 2/20 | 0.73 |
| ▸ | HDAC11 | Q96DB2 | 2/20 | 0.73 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.73 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.73 |
| ▸ | KDM1A | O60341 | 8/20 | 0.65 |
| ▸ | MAOA | P21397 | 8/20 | 0.65 |
| ▸ | MAOB | P27338 | 8/20 | 0.65 |
| ▸ | RCOR1 | Q9UKL0 | 3/20 | 0.65 |
| ▸ | NPC1 | O15118 | 3/20 | 0.65 |
| ▸ | RAB9A | P51151 | 3/20 | 0.65 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.65 |
| ▸ | KDM1B | Q8NB78 | 1/20 | 0.65 |
| ▸ | DEGS1 | O15121 | 1/20 | 0.63 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.62 |
| ▸ | SIRT1 | Q96EB6 | 1/20 | 0.61 |
| ▸ | MEN1 | O00255 | 1/20 | 0.61 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.61 |
| ▸ | POLB | P06746 | 1/20 | 0.61 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.60 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2568499 | 0.93 | HDAC8 (0.73) | HDAC3HDAC11HDAC8HDAC6KDM1A | |
| SCHEMBL2565608 | 0.92 | HDAC8 (0.76) | HDAC3HDAC11HDAC8HDAC6KDM1A | |
| SCHEMBL26154132 | 0.87 | HDAC8 (0.68) | HDAC3HDAC11HDAC8HDAC6KDM1A | |
| SCHEMBL13389686 | 0.84 | NPC1 (0.71) | HDAC3HDAC11HDAC8HDAC6KDM1A | |
| SCHEMBL3302853 | 0.84 | NPC1 (0.71) | HDAC3HDAC11HDAC8HDAC6KDM1A | |
| SCHEMBL29537051 | 0.84 | JAK3 (0.75) | — | |
| SCHEMBL1992113 | 0.84 | JAK3 (0.75) | — | |
| SCHEMBL22334947 | 0.83 | HDAC3 (0.57) | HDAC3HDAC11HDAC8HDAC6KDM1A | |
| SCHEMBL126415 | 0.83 | PTPN1 (0.87) | HDAC8HDAC6NPC1RAB9AKDM4E | |
| SCHEMBL18553776 | 0.83 | P2RY14 (0.66) | HDAC3HDAC11HDAC8HDAC6MAOA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2382194-A2 | COMPOUNDS FOR THE PREVENTION AND TREATMENT OF CARDIOVASCULAR DISEASE | RESVERLOGIX CORP. (CA) | 2011-11-02 | — | — | EP | disclosed |