Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | S1PR1 | P21453 | 18/20 | 0.60 |
| ▸ | S1PR4 | O95977 | 1/20 | 0.53 |
| ▸ | S1PR5 | Q9H228 | 1/20 | 0.53 |
| ▸ | CYP11B1 | P15538 | 2/20 | 0.44 |
| ▸ | CYP11B2 | P19099 | 2/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2567213 | 0.87 | S1PR1 (0.64) | S1PR1S1PR4S1PR5CYP11B1CYP11B2 | |
| SCHEMBL2567772 | 0.87 | S1PR1 (0.64) | S1PR1S1PR4S1PR5CYP11B1CYP11B2 | |
| SCHEMBL2559277 | 0.87 | S1PR1 (0.69) | S1PR1S1PR4S1PR5CYP11B1CYP11B2 | |
| SCHEMBL2567601 | 0.86 | S1PR1 (0.73) | S1PR1S1PR4S1PR5CYP11B1CYP11B2 | |
| SCHEMBL2562566 | 0.85 | S1PR1 (0.62) | S1PR1S1PR4S1PR5CYP11B1CYP11B2 | |
| SCHEMBL2565306 | 0.85 | S1PR1 (0.65) | S1PR1S1PR4S1PR5 | |
| SCHEMBL2564330 | 0.84 | S1PR1 (0.73) | S1PR1S1PR4S1PR5CYP11B1CYP11B2 | |
| SCHEMBL2567689 | 0.84 | S1PR1 (0.62) | S1PR1S1PR4S1PR5CYP11B1CYP11B2 | |
| SCHEMBL2561598 | 0.84 | S1PR1 (0.59) | S1PR1S1PR4S1PR5CYP11B1CYP11B2 | |
| SCHEMBL2569367 | 0.83 | S1PR1 (0.71) | S1PR1S1PR4S1PR5CYP11B1CYP11B2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2222668-B1 | TETRAHYDROCYCLOPENTA[B]INDOL-3-YL CARBOXYLIC ACID DERIVATIVES USEFUL IN THE TREATMENT OF AUTOIMMUNE AND INFLAMMATORY DISORDERS | ARENA PHARM INC (US) | 2011-11-02 | — | — | EP | disclosed |