Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AVPR1A | P37288 | 19/20 | 0.56 |
| ▸ | KCNH2 | Q12809 | 5/20 | 0.39 |
| ▸ | AVPR2 | P30518 | 1/20 | 0.36 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2548275 | 0.89 | AVPR1A (0.60) | AVPR1AKCNH2AVPR2 | |
| SCHEMBL2548274 | 0.89 | AVPR1A (0.60) | AVPR1AKCNH2AVPR2 | |
| SCHEMBL2560491 | 0.87 | AVPR1A (0.56) | AVPR1AKCNH2AVPR2CYP11B2 | |
| SCHEMBL2557454 | 0.84 | AVPR1A (0.53) | AVPR1AKCNH2CYP11B2 | |
| Hydrochloric Acid SCHEMBL2563294 | 0.83 | AVPR1A (0.52) | AVPR1AKCNH2AVPR2 | |
| SCHEMBL2565815 | 0.83 | AVPR1A (0.71) | AVPR1AKCNH2AVPR2 | |
| SCHEMBL2565595 | 0.82 | AVPR1A (0.57) | AVPR1AKCNH2AVPR2 | |
| SCHEMBL2563325 | 0.79 | AVPR1A (0.54) | AVPR1AKCNH2AVPR2CYP11B2 | |
| SCHEMBL2543941 | 0.79 | AVPR1A (0.58) | AVPR1AKCNH2AVPR2 | |
| SCHEMBL2540782 | 0.79 | AVPR1A (0.58) | AVPR1AKCNH2AVPR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2560975-A1 | HETEROARYL-CYCLOHEXYL-TETRAAZABENZO[E]AZULENES AS VASOPRESSIN V1A RECEPTOR ANTAGONISTS | F. Hoffmann-La Roche AG (CH) | 2013-02-27 | — | — | EP | claimed |
| WO-2011131596-A1 | HETEROARYL-CYCLOHEXYL-TETRAAZABENZO[E]AZULENES AS VASOPRESSIN V1A RECEPTOR ANTAGONISTS | F. HOFFMANN-LA ROCHE AG (CH) | 2011-10-27 | — | — | WO | claimed |
| EP-2560975-A1 | HETEROARYL-CYCLOHEXYL-TETRAAZABENZO[E]AZULENES AS VASOPRESSIN V1A RECEPTOR ANTAGONISTS | F. Hoffmann-La Roche AG (CH) | 2013-02-27 | — | — | EP | disclosed |
| WO-2011131596-A1 | HETEROARYL-CYCLOHEXYL-TETRAAZABENZO[E]AZULENES AS VASOPRESSIN V1A RECEPTOR ANTAGONISTS | F. HOFFMANN-LA ROCHE AG (CH) | 2011-10-27 | — | — | WO | disclosed |