Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH4 | Q9H3N8 | 15/20 | 0.51 |
| ▸ | HRH3 | Q9Y5N1 | 4/20 | 0.34 |
| ▸ | HTR3A | P46098 | 1/20 | 0.33 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.32 |
| ▸ | PIK3R1 | P27986 | 1/20 | 0.31 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL603609 | 1.00 | HRH4 (0.51) | HRH4HRH3HTR3AROCK1PIK3R1 | |
| SCHEMBL3230075 | 0.86 | HRH4 (0.52) | HRH4HRH3HTR3AROCK1 | |
| SCHEMBL3230086 | 0.86 | HRH4 (0.52) | HRH4HRH3HTR3AROCK1 | |
| SCHEMBL606357 | 0.84 | HRH4 (0.64) | HRH4HRH3HTR3AROCK1 | |
| SCHEMBL18550564 | 0.84 | HRH4 (0.64) | HRH4HRH3HTR3AROCK1 | |
| SCHEMBL18550565 | 0.84 | HRH4 (0.64) | HRH4HRH3HTR3AROCK1 | |
| SCHEMBL604782 | 0.84 | HRH4 (0.64) | HRH4HRH3HTR3AROCK1 | |
| SCHEMBL604783 | 0.84 | HRH4 (0.64) | HRH4HRH3HTR3AROCK1 | |
| SCHEMBL606814 | 0.81 | HRH4 (0.37) | HRH4HRH3 | |
| SCHEMBL606339 | 0.80 | HRH4 (0.54) | HRH4HRH3HTR3AROCK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2382013-A1 | SELECTIVE HISTAMINE H4 RECEPTOR ANTAGONISTS FOR THE TREATMENT OF VESTIBULAR DISORDERS. | INSERM (Institut National de la Santé et de la Recherche Médicale) (FR) | 2011-11-02 | — | — | EP | disclosed |
| WO-2010072829-A1 | SELECTIVE HISTAMINE H4 RECEPTOR ANTAGONISTS FOR THE TREATMENT OF VESTIBULAR DISORDERS. | INSERM (Institut National de la Santé et de la Recherche Médicale) (FR) | 2010-07-01 | — | — | WO | disclosed |