SCHEMBL25669487

SCHEMBL25669487

O=C1CCCN1c1ccc(S)cn1

nearest known ligand 0.52

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CNR2 P34972 1/20 0.52
PARP1 P09874 3/20 0.48
CCNC P24863 1/20 0.40
CDK8 P49336 1/20 0.40
ALDH1A1 P00352 2/20 0.39
PCSK9 Q8NBP7 1/20 0.37
L3MBTL1 Q9Y468 1/20 0.36
AR P10275 1/20 0.36
FGFR3 P22607 1/20 0.36
HRH3 Q9Y5N1 2/20 0.36
PIM1 P11309 2/20 0.36
CYP1A2 P05177 1/20 0.36
CYP3A4 P08684 1/20 0.36
CYP2D6 P10635 1/20 0.36
CYP2C9 P11712 1/20 0.36
HPGD P15428 1/20 0.36
CYP2C19 P33261 1/20 0.36
AKR1C3 P42330 2/20 0.35
HPGDS O60760 1/20 0.35
PIM3 Q86V86 1/20 0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL14910345 0.81 CNR2 (0.53) CNR2PARP1CCNCCDK8ALDH1A1
SCHEMBL38010 0.80 CNR2 (0.52) CNR2PARP1CCNCCDK8ALDH1A1
SCHEMBL30470842 0.80 CNR2 (0.52) CNR2PARP1CCNCCDK8ALDH1A1
SCHEMBL31202632 0.80 CNR2 (0.52) CNR2PARP1CCNCCDK8ALDH1A1
SCHEMBL469807 0.80 CNR2 (0.52) CNR2PARP1CCNCCDK8ALDH1A1
SCHEMBL46340 0.80 CNR2 (0.52) CNR2PARP1CCNCCDK8ALDH1A1
SCHEMBL2645643 0.80 CNR2 (0.56) CNR2PARP1CCNCCDK8ALDH1A1
SCHEMBL77785 0.77 CNR2 (0.49) CNR2PARP1CCNCCDK8ALDH1A1
SCHEMBL23930181 0.76 CNR2 (0.49) CNR2PARP1CCNCCDK8PCSK9
SCHEMBL469819 0.76 CNR2 (0.49) CNR2PARP1CCNCCDK8ALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2023109883-A1 AROMATIC HETEROCYCLE-SUBSTITUTED COMPOUNDS, AND PREPARATION METHOD THEREFOR AND USE THEREOF 上海翊石医药科技有限公司 2023-06-22 WO disclosed