Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE5A | O76074 | 20/20 | 0.68 |
| ▸ | PDE6D | O43924 | 3/20 | 0.57 |
| ▸ | PDE6A | P16499 | 3/20 | 0.57 |
| ▸ | PDE6G | P18545 | 3/20 | 0.57 |
| ▸ | PDE6B | P35913 | 3/20 | 0.57 |
| ▸ | PDE6C | P51160 | 3/20 | 0.57 |
| ▸ | PDE6H | Q13956 | 3/20 | 0.57 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2567781 | 0.96 | PDE5A (0.67) | PDE5APDE6DPDE6APDE6GPDE6B | |
| SCHEMBL2566212 | 0.85 | PDE5A (0.68) | PDE5APDE6C | |
| SCHEMBL2567776 | 0.82 | PDE5A (0.69) | PDE5APDE6DPDE6APDE6GPDE6B | |
| SCHEMBL2565446 | 0.81 | PDE5A (1.00) | PDE5APDE6DPDE6APDE6GPDE6B | |
| SCHEMBL2567460 | 0.81 | PDE5A (1.00) | PDE5APDE6DPDE6APDE6GPDE6B | |
| SCHEMBL2568504 | 0.80 | PDE5A (0.66) | PDE5APDE6DPDE6APDE6GPDE6B | |
| SCHEMBL2567778 | 0.80 | PDE5A (0.92) | PDE5APDE6DPDE6APDE6GPDE6B | |
| SCHEMBL2564842 | 0.73 | PDE5A (1.00) | PDE5APDE6DPDE6APDE6GPDE6B | |
| SCHEMBL2576880 | 0.72 | PDE5A (1.00) | PDE5APDE6DPDE6APDE6GPDE6B | |
| SCHEMBL2568303 | 0.71 | PDE5A (0.69) | PDE5APDE6DPDE6APDE6GPDE6B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2383262-B1 | PHENYL PYRIMIDONE COMPOUNDS, PHARMACEUTICAL COMPOSITIONS, PREPARATION METHODS AND USES THEREOF | TOPHARMAN SHANGHAI CO LTD (CN) | 2016-07-06 | — | — | EP | disclosed |
| EP-2383262-A1 | PHENYL PYRIMIDONE COMPOUNDS, PHARMACEUTICAL COMPOSITIONS, PREPARATION METHODS AND USES THEREOF | Topharman Shanghai Co., Ltd. (CN) | 2011-11-02 | — | — | EP | disclosed |