Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK2 | O60674 | 3/20 | 0.73 |
| ▸ | JAK3 | P52333 | 2/20 | 0.73 |
| ▸ | NTRK1 | P04629 | 16/20 | 0.69 |
| ▸ | LIMK1 | P53667 | 1/20 | 0.52 |
| ▸ | LIMK2 | P53671 | 1/20 | 0.52 |
| ▸ | IGF1R | P08069 | 3/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2567637 | 1.00 | JAK2 (0.73) | JAK2JAK3NTRK1LIMK1LIMK2 | |
| SCHEMBL5027435 | 0.91 | JAK2 (0.73) | JAK2JAK3NTRK1LIMK1LIMK2 | |
| SCHEMBL5027437 | 0.91 | JAK2 (0.73) | JAK2JAK3NTRK1LIMK1LIMK2 | |
| SCHEMBL5032152 | 0.90 | JAK2 (0.74) | JAK2JAK3NTRK1LIMK1LIMK2 | |
| SCHEMBL5027420 | 0.88 | JAK2 (0.76) | JAK2JAK3NTRK1LIMK1LIMK2 | |
| SCHEMBL2577694 | 0.87 | NTRK1 (0.75) | JAK2JAK3NTRK1LIMK1LIMK2 | |
| SCHEMBL2577688 | 0.87 | NTRK1 (0.75) | JAK2JAK3NTRK1LIMK1LIMK2 | |
| SCHEMBL2570018 | 0.87 | NTRK1 (0.63) | JAK2JAK3NTRK1 | |
| SCHEMBL2577543 | 0.87 | NTRK1 (0.63) | JAK2JAK3NTRK1 | |
| SCHEMBL2578229 | 0.86 | NTRK1 (0.78) | JAK2JAK3NTRK1LIMK1LIMK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2383268-A1 | Pyrazolylaminopyridine derivatives useful as kinase inhibitors | AstraZeneca AB (SE) | 2011-11-02 | — | — | EP | disclosed |