Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CRBN | Q96SW2 | 16/20 | 0.61 |
| ▸ | DDB1 | Q16531 | 7/20 | 0.61 |
| ▸ | IKZF3 | Q9UKT9 | 5/20 | 0.52 |
| ▸ | IKZF1 | Q13422 | 2/20 | 0.52 |
| ▸ | BRD4 | O60885 | 1/20 | 0.52 |
| ▸ | TNF | P01375 | 1/20 | 0.52 |
| ▸ | IL1B | P01584 | 1/20 | 0.52 |
| ▸ | MAP1LC3B | Q9GZQ8 | 2/20 | 0.48 |
| ▸ | CSNK1A1 | P48729 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.44 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.44 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.44 |
| ▸ | TSHR | P16473 | 1/20 | 0.44 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.44 |
| ▸ | IKZF2 | Q9UKS7 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19504240 | 0.91 | CRBN (0.53) | CRBNDDB1IKZF3IKZF1BRD4 | |
| SCHEMBL21304408 | 0.90 | CRBN (0.66) | CRBNDDB1IKZF3IKZF1BRD4 | |
| SCHEMBL18666833 | 0.90 | CRBN (0.66) | CRBNDDB1IKZF3IKZF1BRD4 | |
| SCHEMBL25477254 | 0.84 | CRBN (0.52) | CRBNDDB1IKZF3IKZF1BRD4 | |
| SCHEMBL20992933 | 0.82 | CRBN (0.64) | CRBNDDB1IKZF3IKZF1BRD4 | |
| SCHEMBL20652915 | 0.81 | CRBN (0.41) | CRBNDDB1IKZF3IKZF1BRD4 | |
| SCHEMBL25034866 | 0.80 | CRBN (0.53) | CRBNDDB1IKZF3IKZF1BRD4 | |
| SCHEMBL25766116 | 0.80 | CRBN (0.61) | CRBNDDB1IKZF3IKZF1BRD4 | |
| SCHEMBL25036779 | 0.79 | CRBN (0.80) | CRBNDDB1IKZF3IKZF1BRD4 | |
| SCHEMBL25034710 | 0.79 | CRBN (0.63) | CRBNDDB1IKZF3IKZF1BRD4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230181746-A1 | BENZOYLHYDRAZIDE-DERIVED HDAC DEGRADERS AS THERAPEUTICS FOR TREATING CANCER AND OTHER HUMAN DISEASES | UNIVERSITY OF FLORIDA RESEARCH FOUNDATION, INC. | 2023-06-15 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230181746-A1 | BENZOYLHYDRAZIDE-DERIVED HDAC DEGRADERS AS THERAPEUTICS FOR TREATING CANCER AND OTHER HUMAN DISEASES | HDAC3, HDAC1, HDAC5 | CRBN 208/4885DDB1 683/4885IKZF3 212/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.