Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PKMYT1 | Q99640 | 2/20 | 0.35 |
| ▸ | JAK2 | O60674 | 3/20 | 0.35 |
| ▸ | CDK1 | P06493 | 1/20 | 0.35 |
| ▸ | CDK4 | P11802 | 1/20 | 0.35 |
| ▸ | CCND1 | P24385 | 1/20 | 0.35 |
| ▸ | CDK2 | P24941 | 1/20 | 0.35 |
| ▸ | ALK | Q9UM73 | 2/20 | 0.34 |
| ▸ | MAPK8 | P45983 | 2/20 | 0.34 |
| ▸ | MAPK9 | P45984 | 1/20 | 0.34 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.34 |
| ▸ | JAK3 | P52333 | 2/20 | 0.34 |
| ▸ | STAT6 | P42226 | 2/20 | 0.34 |
| ▸ | SLC2A1 | P11166 | 2/20 | 0.34 |
| ▸ | SYK | P43405 | 3/20 | 0.34 |
| ▸ | AURKA | O14965 | 1/20 | 0.34 |
| ▸ | EGFR | P00533 | 1/20 | 0.34 |
| ▸ | IGF1R | P08069 | 2/20 | 0.33 |
| ▸ | INSR | P06213 | 1/20 | 0.33 |
| ▸ | PTK2 | Q05397 | 1/20 | 0.33 |
| ▸ | PTK2B | Q14289 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1115314 | 0.86 | ALK (0.41) | PKMYT1JAK2CDK1CDK4CCND1 | |
| SCHEMBL1115161 | 0.79 | CDK4 (0.47) | CDK1CDK4CCND1CDK2 | |
| SCHEMBL12162407 | 0.78 | CCND3 (0.52) | PKMYT1JAK2CDK1CDK4CCND1 | |
| SCHEMBL1644121 | 0.73 | CDK4 (0.37) | JAK2CDK1CDK4CCND1CDK2 | |
| SCHEMBL1115321 | 0.69 | ALK (0.42) | CDK1CDK4CCND1CDK2ALK | |
| SCHEMBL1115440 | 0.68 | CDK4 (0.48) | CDK4CCND1CDK2MAPK8MAPK9 | |
| SCHEMBL1115132 | 0.68 | STAT6 (0.44) | JAK2CDK4CCND1ALKSTAT6 | |
| SCHEMBL1115284 | 0.67 | CDK4 (0.49) | CDK4CCND1CDK2STAT6 | |
| SCHEMBL1115360 | 0.65 | PIK3CA (0.34) | — | |
| SCHEMBL1115182 | 0.65 | CDK4 (0.48) | CDK1CDK4CCND1CDK2ALK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2278973-B1 | GEM-DISUBSTITUTED AND SPIROCYCLIC AMINO PYRIDINES/PYRIMIDINES AS CELL CYCLE INHIBITORS | AMGEN INC (US) | 2011-11-02 | — | — | EP | disclosed |