Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CA | P42336 | 14/20 | 0.42 |
| ▸ | PIK3CB | P42338 | 6/20 | 0.41 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.41 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
| ▸ | MTOR | P42345 | 1/20 | 0.38 |
| ▸ | PRKDC | P78527 | 1/20 | 0.38 |
| ▸ | PIK3C3 | Q8NEB9 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31516612 | 0.94 | PIK3CA (0.44) | PIK3CAPIK3CBPIK3CDPIK3CGMTOR | |
| SCHEMBL25681460 | 0.94 | PIK3CA (0.44) | PIK3CAPIK3CBPIK3CDPIK3CGMTOR | |
| SCHEMBL30434249 | 0.93 | PIK3CA (0.50) | PIK3CAPIK3CBPIK3CDPIK3CGMTOR | |
| SCHEMBL25676471 | 0.93 | PIK3CA (0.50) | PIK3CAPIK3CBPIK3CDPIK3CGMTOR | |
| SCHEMBL25677293 | 0.90 | PIK3CA (0.48) | PIK3CAPIK3CBPIK3CDPIK3CGMTOR | |
| SCHEMBL31516551 | 0.90 | PIK3CA (0.48) | PIK3CAPIK3CBPIK3CDPIK3CGMTOR | |
| SCHEMBL31516559 | 0.88 | PIK3CA (0.47) | PIK3CAPIK3CBPIK3CDPIK3CGMTOR | |
| SCHEMBL25678736 | 0.88 | PIK3CA (0.47) | PIK3CAPIK3CBPIK3CDPIK3CGMTOR | |
| SCHEMBL25273528 | 0.88 | PIK3CA (0.50) | PIK3CAPIK3CBPIK3CDPIK3CGMTOR | |
| SCHEMBL30434672 | 0.88 | PIK3CA (0.50) | PIK3CAPIK3CBPIK3CDPIK3CGMTOR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023104111-A1 | FUSED HETEROCYCLIC COMPOUNDS AS PI3KALPHA INHIBITORS | NANJING ZENSHINE PHARMACEUTICALS CO., LTD. (CN) | 2023-06-15 | — | — | WO | disclosed |