Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH4 | Q9H3N8 | 7/20 | 0.41 |
| ▸ | USP30 | Q70CQ3 | 1/20 | 0.39 |
| ▸ | CCNT1 | O60563 | 3/20 | 0.38 |
| ▸ | CDK9 | P50750 | 3/20 | 0.38 |
| ▸ | USP1 | O94782 | 2/20 | 0.38 |
| ▸ | WDR48 | Q8TAF3 | 2/20 | 0.38 |
| ▸ | MAP3K12 | Q12852 | 1/20 | 0.36 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.35 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.35 |
| ▸ | IRAK4 | Q9NWZ3 | 3/20 | 0.34 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.34 |
| ▸ | GPR39 | O43194 | 1/20 | 0.34 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18672935 | 0.89 | IRAK4 (0.43) | HRH4USP30CCNT1CDK9USP1 | |
| SCHEMBL18466042 | 0.88 | HRH4 (0.48) | HRH4USP30CCNT1CDK9USP1 | |
| SCHEMBL18466141 | 0.85 | HRH4 (0.50) | HRH4USP30CCNT1CDK9ROCK2 | |
| SCHEMBL25692593 | 0.82 | HRH4 (0.44) | HRH4USP30MAP3K12ROCK2ROCK1 | |
| SCHEMBL25692677 | 0.82 | HRH4 (0.39) | HRH4USP30MAP3K12ROCK2ROCK1 | |
| SCHEMBL20252214 | 0.81 | IRAK4 (0.41) | HRH4CCNT1CDK9MAP3K12IRAK4 | |
| SCHEMBL18672881 | 0.80 | HRH4 (0.54) | HRH4CCNT1CDK9ROCK2ROCK1 | |
| SCHEMBL25692595 | 0.80 | CCNT1 (0.43) | HRH4CCNT1CDK9ROCK2ROCK1 | |
| SCHEMBL19171712 | 0.76 | BRD4 (0.49) | HRH4CCNT1CDK9ROCK2ROCK1 | |
| SCHEMBL19606453 | 0.75 | HRH4 (0.48) | HRH4MAP3K12 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023108108-A1 | RAF KINASE INHIBITORS AND METHODS OF USE THEREOF | DECIPHERA PHARMACEUTICALS, LLC (US) | 2023-06-15 | — | — | WO | disclosed |