Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALK | Q9UM73 | 1/20 | 0.45 |
| ▸ | AXL | P30530 | 6/20 | 0.44 |
| ▸ | STAT6 | P42226 | 2/20 | 0.43 |
| ▸ | SYK | P43405 | 7/20 | 0.43 |
| ▸ | TNK2 | Q07912 | 1/20 | 0.43 |
| ▸ | CDK4 | P11802 | 2/20 | 0.42 |
| ▸ | CCND1 | P24385 | 2/20 | 0.42 |
| ▸ | CCND2 | P30279 | 1/20 | 0.42 |
| ▸ | CCND3 | P30281 | 1/20 | 0.42 |
| ▸ | IGF1R | P08069 | 1/20 | 0.42 |
| ▸ | CDK2 | P24941 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1115374 | 0.87 | CCND3 (0.57) | ALKAXLSYKCDK4CCND1 | |
| SCHEMBL1644117 | 0.86 | CDK4 (0.39) | ALKAXLSTAT6SYKTNK2 | |
| SCHEMBL1115244 | 0.85 | CDK4 (0.49) | STAT6SYKCDK4CCND1CCND2 | |
| SCHEMBL1115321 | 0.84 | ALK (0.42) | ALKAXLSTAT6SYKCDK4 | |
| SCHEMBL1115476 | 0.82 | CDK2 (0.45) | STAT6TNK2CDK4CCND1CCND2 | |
| SCHEMBL1115315 | 0.82 | TNK2 (0.55) | ALKTNK2CDK4CCND1CCND2 | |
| SCHEMBL1115436 | 0.80 | WEE1 (0.47) | STAT6CDK4CCND1CCND2CCND3 | |
| SCHEMBL1115415 | 0.79 | TNK2 (0.52) | ALKTNK2CDK4CCND1CCND2 | |
| SCHEMBL1115422 | 0.77 | CDK4 (0.49) | STAT6TNK2CDK4CCND1CCND2 | |
| SCHEMBL1115453 | 0.77 | LRRK2 (0.53) | AXLSTAT6SYKCDK4CCND3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2278973-B1 | GEM-DISUBSTITUTED AND SPIROCYCLIC AMINO PYRIDINES/PYRIMIDINES AS CELL CYCLE INHIBITORS | AMGEN INC (US) | 2011-11-02 | — | — | EP | claimed |