Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOTUM | Q6P988 | 5/20 | 0.47 |
| ▸ | PDE3B | Q13370 | 10/20 | 0.46 |
| ▸ | PDE3A | Q14432 | 10/20 | 0.46 |
| ▸ | KDR | P35968 | 1/20 | 0.39 |
| ▸ | HRH3 | Q9Y5N1 | 4/20 | 0.39 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1769918 | 0.88 | PDE3B (0.59) | NOTUMPDE3BPDE3AKDRHRH3 | |
| SCHEMBL13071051 | 0.85 | NOTUM (0.62) | NOTUMPDE3BPDE3AKDRHRH3 | |
| SCHEMBL13071050 | 0.84 | NOTUM (0.61) | NOTUMPDE3BPDE3AKDRHRH3 | |
| SCHEMBL1769796 | 0.84 | NOTUM (0.61) | NOTUMPDE3BPDE3AKDRHRH3 | |
| SCHEMBL29113210 | 0.84 | PDE3B (0.46) | NOTUMPDE3BPDE3AKDR | |
| SCHEMBL25189703 | 0.83 | HRH3 (0.39) | KDRHRH3KCNH2 | |
| SCHEMBL30416695 | 0.83 | HRH3 (0.39) | KDRHRH3KCNH2 | |
| SCHEMBL12649105 | 0.83 | PDE3B (0.47) | NOTUMPDE3BPDE3AKDRHRH3 | |
| SCHEMBL13071350 | 0.83 | NOTUM (0.54) | NOTUMPDE3BPDE3AKDR | |
| SCHEMBL12649035 | 0.83 | NOTUM (0.51) | NOTUMPDE3BPDE3AKDR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023088477-A1 | MULTIFUNCTIONAL COMPOUND CAPABLE OF DEGRADING BTK KINASE, AND COMPOSITION AND USE | 杭州和正医药有限公司 | 2023-05-25 | — | — | WO | disclosed |