Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AKT1 | P31749 | 3/20 | 0.45 |
| ▸ | CTSS | P25774 | 4/20 | 0.43 |
| ▸ | CTSL | P07711 | 3/20 | 0.43 |
| ▸ | CTSB | P07858 | 3/20 | 0.43 |
| ▸ | IDO1 | P14902 | 1/20 | 0.42 |
| ▸ | SYK | P43405 | 1/20 | 0.41 |
| ▸ | NPFFR1 | Q9GZQ6 | 1/20 | 0.40 |
| ▸ | NPFFR2 | Q9Y5X5 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | CA12 | O43570 | 1/20 | 0.39 |
| ▸ | CA1 | P00915 | 1/20 | 0.39 |
| ▸ | CA7 | P43166 | 1/20 | 0.39 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.39 |
| ▸ | SIGMAR1 | Q99720 | 3/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
| ▸ | JAK2 | O60674 | 1/20 | 0.37 |
| ▸ | JAK1 | P23458 | 1/20 | 0.37 |
| ▸ | CTSK | P43235 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25698474 | 1.00 | AKT1 (0.45) | AKT1CTSSCTSLCTSBIDO1 | |
| SCHEMBL25572358 | 0.83 | AKT1 (0.44) | AKT1CTSSCTSLCTSBIDO1 | |
| SCHEMBL25698468 | 0.83 | AKT1 (0.44) | AKT1CTSSCTSLCTSBIDO1 | |
| SCHEMBL25572361 | 0.83 | AKT1 (0.44) | AKT1CTSSCTSLCTSBIDO1 | |
| SCHEMBL13664871 | 0.78 | AKT1 (0.52) | AKT1CTSSCTSLCTSBIDO1 | |
| SCHEMBL6185852 | 0.74 | NAMPT (0.44) | IDO1SYKNPFFR1NPFFR2 | |
| SCHEMBL25568275 | 0.74 | KDM4E (0.39) | ALDH1A1KMT2A | |
| SCHEMBL25568276 | 0.74 | KDM4E (0.39) | ALDH1A1KMT2A | |
| SCHEMBL6863653 | 0.73 | KDM1A (0.57) | AKT1CTSSCTSLCTSBALDH1A1 | |
| SCHEMBL21071384 | 0.73 | KDM1A (0.57) | AKT1CTSSCTSLCTSBALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023091438-A1 | CHROMANE AMIDINE MONOBACTAM ANTIBIOTICS | MERCK SHARP & DOHME LLC (US) | 2023-05-25 | — | — | WO | disclosed |