Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK1 | P23458 | 19/20 | 0.63 |
| ▸ | JAK2 | O60674 | 16/20 | 0.63 |
| ▸ | AURKA | O14965 | 1/20 | 0.58 |
| ▸ | PRKCA | P17252 | 1/20 | 0.58 |
| ▸ | KDR | P35968 | 1/20 | 0.58 |
| ▸ | TYK2 | P29597 | 2/20 | 0.55 |
| ▸ | JAK3 | P52333 | 2/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25700550 | 0.94 | JAK1 (0.65) | JAK1JAK2AURKAPRKCAKDR | |
| SCHEMBL25699325 | 0.89 | JAK2 (0.65) | JAK1JAK2AURKAPRKCAKDR | |
| SCHEMBL27439929 | 0.88 | JAK1 (0.61) | JAK1JAK2TYK2JAK3 | |
| SCHEMBL27432584 | 0.88 | JAK1 (0.61) | JAK1JAK2TYK2JAK3 | |
| SCHEMBL25242401 | 0.87 | JAK1 (0.75) | JAK1JAK2TYK2JAK3 | |
| SCHEMBL29460506 | 0.87 | JAK1 (0.75) | JAK1JAK2TYK2JAK3 | |
| SCHEMBL25284195 | 0.87 | JAK1 (0.75) | JAK1JAK2TYK2JAK3 | |
| SCHEMBL27438133 | 0.86 | JAK1 (0.46) | JAK1JAK2AURKAPRKCAKDR | |
| SCHEMBL27436904 | 0.85 | JAK1 (0.80) | JAK1JAK2AURKAPRKCAKDR | |
| SCHEMBL2277478 | 0.85 | JAK1 (0.75) | JAK1JAK2AURKAPRKCAKDR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4393923-A1 | PYRIDO RING COMPOUND, PREPARATION METHOD THEREFOR, INTERMEDIATE, COMPOSITION, AND APPLICATION | Yiyou Biotech (Shanghai) Co., Ltd. (CN) | 2024-07-03 | — | — | EP | disclosed |
| WO-2023115327-A1 | PYRIDO RING COMPOUND, PREPARATION METHOD THEREFOR, INTERMEDIATE, COMPOSITION, AND APPLICATION | 中国药科大学 | 2023-06-29 | — | — | WO | disclosed |