Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 2/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | RECQL | P46063 | 1/20 | 0.43 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.43 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.42 |
| ▸ | USP2 | O75604 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | GPR119 | Q8TDV5 | 3/20 | 0.40 |
| ▸ | JAK2 | O60674 | 1/20 | 0.40 |
| ▸ | JAK1 | P23458 | 1/20 | 0.40 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.40 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.40 |
| ▸ | DPP4 | P27487 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | THRB | P10828 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL408276 | 0.91 | HPGD (0.50) | HPGDMAPTALDH1A1RECQLEPHX1 | |
| SCHEMBL25177622 | 0.88 | NR1H2 (0.46) | HPGDMAPTMEN1ALDH1A1KMT2A | |
| SCHEMBL1999986 | 0.84 | HPGD (0.46) | HPGDMAPTMEN1ALDH1A1KMT2A | |
| SCHEMBL4552184 | 0.81 | HPGD (0.47) | HPGDMAPTRECQLEPHX1USP2 | |
| SCHEMBL21797974 | 0.81 | HPGD (0.41) | HPGDMAPTMEN1ALDH1A1KMT2A | |
| SCHEMBL31319964 | 0.80 | HPGD (0.50) | HPGDMAPTMEN1ALDH1A1KMT2A | |
| SCHEMBL22680124 | 0.80 | HPGD (0.50) | HPGDMAPTMEN1ALDH1A1KMT2A | |
| SCHEMBL23207055 | 0.80 | HPGD (0.50) | HPGDMAPTMEN1ALDH1A1KMT2A | |
| SCHEMBL24541794 | 0.79 | MEN1 (0.50) | HPGDMAPTMEN1ALDH1A1KMT2A | |
| SCHEMBL24261185 | 0.78 | HPGD (0.49) | HPGDMAPTMEN1ALDH1A1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023081840-A1 | KRAS G12C INHIBITORS | FRONTIER MEDICINES CORPORATION (US) | 2023-05-11 | — | — | WO | disclosed |