Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Alclofenac. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PPARD | Q03181 | 2/20 | 0.62 |
| ▸ | GAA | P10253 | 3/20 | 0.54 |
| ▸ | TSHR | P16473 | 3/20 | 0.54 |
| ▸ | CA2 | P00918 | 1/20 | 0.51 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.45 |
| ▸ | NPC1 | O15118 | 3/20 | 0.45 |
| ▸ | RAB9A | P51151 | 3/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.45 |
| ▸ | HPGD | P15428 | 3/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.44 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.44 |
| ▸ | LTB4R | Q15722 | 2/20 | 0.44 |
| ▸ | LTB4R2 | Q9NPC1 | 2/20 | 0.44 |
| ▸ | KDM1A | O60341 | 1/20 | 0.43 |
| ▸ | MRGPRX4 | Q96LA9 | 2/20 | 0.43 |
| ▸ | PTGDR | Q13258 | 1/20 | 0.42 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.42 |
| ▸ | TP53 | P04637 | 2/20 | 0.41 |
| ▸ | MAPT | P10636 | 2/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Alclofenac SCHEMBL29350515 | 1.00 | PPARD (0.62) | PPARDGAATSHRCA2TDP1 | |
| Alclofenac SCHEMBL10600369 | 1.00 | PPARD (0.62) | PPARDGAATSHRCA2TDP1 | |
| Alclofenac SCHEMBL6246536 | 0.99 | PPARD (0.60) | PPARDGAATSHRCA2TDP1 | |
| SCHEMBL11462158 | 0.95 | PPARD (0.57) | PPARDGAATSHRCA2NPC1 | |
| Alclofenac SCHEMBL28898335 | 0.95 | PPARD (0.57) | PPARDGAATSHRCA2TDP1 | |
| Alclofenac SCHEMBL3500031 | 0.92 | PPARD (0.55) | PPARDGAATSHRCA2TDP1 | |
| Alclofenac SCHEMBL3714811 | 0.89 | PPARD (0.52) | PPARDGAATSHRCA2TDP1 | |
| SCHEMBL11460461 | 0.88 | PPARD (0.52) | PPARDGAATSHRCA2NPC1 | |
| SCHEMBL11013101 | 0.88 | GAA (0.50) | PPARDGAATSHRTDP1NPC1 | |
| SCHEMBL11480256 | 0.88 | PPARD (0.51) | PPARDGAATSHRNPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Appears in 14904 patents — a generic fragment claimed broadly, so it's down-weighted as IP noise. Top by claim status then date:
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20260000741-A1 | METHOD OF AMELIORATING A PRO-INFLAMMATORY IMMUNOPHENOTYPE IN FARBER DISEASE SUBJECTS BY REPEATED ADMINISTRATION OF A RECOMBINANT HUMAN ACID CERAMIDASE | ACERAGEN INC (US) | 2026-01-01 | — | — | US | claimed |
| EP-4628080-A1 | PHARMACEUTICAL COMPOSITION FOR PREVENTION OR TREATMENT OF DRUG-RELATED PEPTIC ULCER COMPRISING ZASTAPRAZAN OR PHARMACEUTICALLY ACCEPTABLE SALT THEREOF | Jeil Pharmaceutical Co., Ltd. (KR) | 2025-10-08 | — | — | EP | claimed |
| EP-4525870-A1 | METHODS OF TREATING CUSHING'S SYNDROME AND LIVER DISORDERS, AND OF REDUCING LIVER TOXICITY OF OTHER DRUGS ADMINISTERED TO A PATIENT | Corcept Therapeutics Incorporated (US) | 2025-03-26 | — | — | EP | claimed |
| US-20250041208-A1 | NEW INJECTABLE COMBINATION FORMULATION | NANEXA AB (SE) | 2025-02-06 | — | — | US | claimed |
| CN-119317433-A | Methods for treating cushing's syndrome and liver disease and reducing hepatotoxicity of other drugs taken by patients | 科赛普特治疗学股份有限公司 | 2025-01-14 | — | — | CN | claimed |
| US-12161726-B2 | Biomimetic vesicles and uses thereof | OHIO STATE INNOVATION FOUNDATION (US) | 2024-12-10 | — | — | US | claimed |
| EP-3508501-B1 | USE OF ANTI-CGRP ANTIBODIES AND ANTIBODY FRAGMENTS TO PREVENT OR INHIBIT PHOTOPHOBIA OR LIGHT AVERSION IN SUBJECTS IN NEED THEREOF, ESPECIALLY MIGRAINE SUFFERERS | H LUNDBECK AS (DK) | 2024-11-06 | — | — | EP | claimed |
| EP-4444277-A1 | NEW INJECTABLE COMBINATION FORMULATION | Nanexa AB (SE) | 2024-10-16 | — | — | EP | claimed |
| CN-118647367-A | Novel injectable combination formulations | 南爱克萨股份公司 | 2024-09-13 | — | — | CN | claimed |
| US-20240299348-A1 | MODULATORS OF TRPML, THEIR COMPOSITIONS AND METHODS OF USE | CARAWAY THERAPEUTICS, INC. | 2024-09-12 | — | — | US | claimed |
| EP-0016460-B1 | SALICYLAMIDE ESTERS HAVING THERAPEUTICAL ACTIVITY, PROCESS FOR THEIR PREPARATION AND RELATED PHARMACEUTICAL COMPOSITION | NEOPHARMED S.p.A. (IT) | 1982-07-28 | — | — | EP | claimed |
| EP-0055870-A1 | Pyridylmethyl esters of selected bio-affecting carboxylic acids, process for preparing and pharmaceutical composition comprising the same | MERCK & CO. INC. (US) | 1982-07-14 | — | — | EP | claimed |
| EP-0051278-A1 | Soft tertiary amine esters of bio-affecting carboxylic acids, processes for preparing and a pharmaceutical composition containing the same | MERCK & CO. INC. (US) | 1982-05-12 | — | — | EP | claimed |
| EP-0050385-A1 | Piridoxine derivatives, a process for their preparation and related pharmaceutical compositions | D and D S.r.l. (IT) | 1982-04-28 | — | — | EP | claimed |
| US-4309421-A | Stabilized parenterally administrable solutions | A. NATTERMANN & CIE. GMBH (DE) | 1982-01-05 | — | — | US | claimed |
| EP-0040899-A2 | Method of delivering drug with aid of effervescent activity generated in environment of use | ALZA CORPORATION (US) | 1981-12-02 | — | — | EP | claimed |
| US-4279926-A | PHENYL ALKANOIC ACID SALT OF AN AMINO ACID | SPA-SOCIETA PRODOTTI ANTIBIOTICI S.P.A. (IT) | 1981-07-21 | — | — | US | claimed |
| US-4268685-A | Salicylamide esters and related pharmaceutical composition | NEOPHARMED S.P.A. (IT) | 1981-05-19 | — | — | US | claimed |
| US-4233304-A | ANTIINFLAMMATORY AGENTS | CRINOS INDUSTRIA FARMACOBIOLOGICA S.P.A. (IT) | 1980-11-11 | — | — | US | claimed |
| EP-0016460-A1 | Salicylamide esters having therapeutical activity, process for their preparation and related pharmaceutical composition | NEOPHARMED S.p.A. (IT) | 1980-10-01 | — | — | EP | claimed |