Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DNMT1 | P26358 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 8/20 | 0.35 |
| ▸ | HPGD | P15428 | 7/20 | 0.35 |
| ▸ | MAPT | P10636 | 5/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.35 |
| ▸ | MEN1 | O00255 | 4/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.35 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.35 |
| ▸ | HTT | P42858 | 2/20 | 0.35 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.35 |
| ▸ | CDK5R1 | Q15078 | 1/20 | 0.35 |
| ▸ | NCOA1 | Q15788 | 1/20 | 0.35 |
| ▸ | NCOA3 | Q9Y6Q9 | 1/20 | 0.35 |
| ▸ | RAB9A | P51151 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 5/20 | 0.33 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.33 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.32 |
| ▸ | CES1 | P23141 | 2/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8039547 | 0.89 | DNMT1 (0.48) | DNMT1ALDH1A1HPGDMAPTKDM4E | |
| SCHEMBL8047458 | 0.72 | DNMT1 (0.40) | DNMT1ALDH1A1HPGDMAPTKDM4E | |
| SCHEMBL21189877 | 0.71 | AKT1 (0.43) | ALDH1A1MAPTKDM4EMEN1KMT2A | |
| SCHEMBL13397736 | 0.64 | DNMT1 (0.61) | DNMT1ALDH1A1HPGDMAPTKDM4E | |
| SCHEMBL3331249 | 0.63 | NQO1 (0.50) | DNMT1ALDH1A1HPGDMAPTKDM4E | |
| SCHEMBL19230419 | 0.63 | DNMT1 (0.83) | DNMT1ALDH1A1HPGDMAPTKDM4E | |
| SCHEMBL3327381 | 0.62 | DNMT1 (0.50) | DNMT1ALDH1A1HPGDMAPTKDM4E | |
| SCHEMBL12236188 | 0.61 | DNMT1 (0.67) | DNMT1ALDH1A1HPGDMAPTKDM4E | |
| SCHEMBL7122517 | 0.61 | DNMT1 (0.73) | DNMT1ALDH1A1HPGDMAPTKDM4E | |
| SCHEMBL16144677 | 0.61 | DNMT1 (0.80) | DNMT1ALDH1A1HPGDMAPTKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4180034-A1 | PHARMACEUTICAL COMPOSITION FOR PREVENTING OR TREATING CANCER COMPRISING NAPHTHOQUINONE-BASED COMPOUND AND IMMUNE CHECKPOINT INHIBITOR AS ACTIVE INGREDIENTS | NADIANBIO Ltd. (KR) | 2023-05-17 | — | — | EP | disclosed |