Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LRRK2 | Q5S007 | 9/20 | 0.51 |
| ▸ | MET | P08581 | 3/20 | 0.50 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.45 |
| ▸ | SLCO1B1 | Q9Y6L6 | 1/20 | 0.45 |
| ▸ | SGMS2 | Q8NHU3 | 1/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.42 |
| ▸ | HTR2A | P28223 | 1/20 | 0.42 |
| ▸ | HTR2C | P28335 | 1/20 | 0.42 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.42 |
| ▸ | PTGER1 | P34995 | 1/20 | 0.42 |
| ▸ | NMT2 | O60551 | 1/20 | 0.41 |
| ▸ | NMT1 | P30419 | 1/20 | 0.41 |
| ▸ | FSCN1 | Q16658 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15204962 | 0.95 | LRRK2 (0.55) | LRRK2METSGMS2HTR2AHTR2C | |
| SCHEMBL165714 | 0.89 | LRRK2 (0.53) | LRRK2METCYP3A4AURKB | |
| SCHEMBL256246 | 0.89 | LRRK2 (0.67) | LRRK2METCYP3A4SLCO1B1SGMS2 | |
| SCHEMBL257185 | 0.87 | LRRK2 (0.61) | LRRK2CYP3A4SLCO1B1 | |
| SCHEMBL176196 | 0.87 | LRRK2 (0.68) | LRRK2METSGMS2 | |
| SCHEMBL165664 | 0.86 | HSD17B10 (0.49) | LRRK2CYP3A4SLCO1B1HSD17B10NMT2 | |
| SCHEMBL256499 | 0.85 | CNR1 (0.47) | LRRK2METCYP3A4AURKB | |
| SCHEMBL176062 | 0.84 | LRRK2 (0.54) | LRRK2CYP3A4SLCO1B1 | |
| SCHEMBL175796 | 0.84 | LRRK2 (0.68) | LRRK2METSGMS2 | |
| SCHEMBL256260 | 0.84 | LRRK2 (0.46) | LRRK2CYP3A4SLCO1B1HSD17B10NMT2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012028629-A1 | 2 - (BENZYLOXY) BENZAMIDES AS LRRK2 KINASE INHIBITORS | GLAXO GROUP LIMITED (GB) | 2012-03-08 | — | — | WO | disclosed |