Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IGF1R | P08069 | 13/20 | 0.59 |
| ▸ | PIK3C3 | Q8NEB9 | 1/20 | 0.52 |
| ▸ | NTRK1 | P04629 | 2/20 | 0.51 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.45 |
| ▸ | CDK2 | P24941 | 1/20 | 0.45 |
| ▸ | NUAK1 | O60285 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2569846 | 0.82 | NTRK1 (0.58) | IGF1RNTRK1CCNA2CDK2NUAK1 | |
| SCHEMBL56519 | 0.82 | IGF1R (0.63) | IGF1RPIK3C3NTRK1CCNA2CDK2 | |
| SCHEMBL56620 | 0.81 | IGF1R (0.69) | IGF1RPIK3C3NTRK1 | |
| SCHEMBL3137277 | 0.80 | NUAK1 (0.56) | IGF1RPIK3C3NTRK1NUAK1 | |
| SCHEMBL13055845 | 0.79 | IGF1R (0.52) | IGF1RPIK3C3NTRK1CCNA2CDK2 | |
| SCHEMBL27690862 | 0.79 | IGF1R (0.59) | IGF1RPIK3C3NTRK1 | |
| SCHEMBL2573694 | 0.78 | NTRK1 (0.78) | IGF1RNTRK1NUAK1 | |
| SCHEMBL57094 | 0.77 | IGF1R (0.62) | IGF1RPIK3C3NTRK1 | |
| SCHEMBL2566975 | 0.76 | IGF1R (0.57) | IGF1RNTRK1CCNA2CDK2NUAK1 | |
| SCHEMBL2564629 | 0.76 | NTRK1 (0.68) | IGF1RNTRK1NUAK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2383268-B1 | PYRAZOLYLAMINOPYRIDINE DERIVATIVES USEFUL AS KINASE INHIBITORS | ASTRAZENECA AB (SE) | 2015-09-02 | — | — | EP | disclosed |
| EP-2383268-A1 | Pyrazolylaminopyridine derivatives useful as kinase inhibitors | AstraZeneca AB (SE) | 2011-11-02 | — | — | EP | disclosed |
| EP-1853602-B1 | CHEMICAL COMPOUNDS | ASTRAZENECA AB (SE) | 2010-07-14 | — | — | EP | disclosed |