Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RET | P07949 | 2/20 | 0.68 |
| ▸ | EGFR | P00533 | 19/20 | 0.67 |
| ▸ | KDR | P35968 | 3/20 | 0.65 |
| ▸ | AURKA | O14965 | 1/20 | 0.65 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.65 |
| ▸ | INSR | P06213 | 1/20 | 0.65 |
| ▸ | FBP1 | P09467 | 1/20 | 0.65 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.65 |
| ▸ | FLT4 | P35916 | 1/20 | 0.65 |
| ▸ | CLK1 | P49759 | 1/20 | 0.65 |
| ▸ | EPHB4 | P54760 | 1/20 | 0.65 |
| ▸ | TEK | Q02763 | 1/20 | 0.65 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.65 |
| ▸ | RIPK2 | O43353 | 1/20 | 0.65 |
| ▸ | KIF5B | P33176 | 1/20 | 0.65 |
| ▸ | NOD1 | Q9Y239 | 1/20 | 0.65 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25735856 | 0.90 | RET (0.55) | RETEGFRKDRAURKAERBB2 | |
| SCHEMBL14863005 | 0.89 | EGFR (0.84) | EGFRKDRAURKAERBB2INSR | |
| SCHEMBL13498209 | 0.88 | EGFR (0.64) | RETEGFRKDRAURKAERBB2 | |
| SCHEMBL19885272 | 0.88 | EGFR (0.64) | RETEGFRKDRAURKAERBB2 | |
| SCHEMBL19006946 | 0.88 | EGFR (0.81) | RETEGFRKDRAURKAERBB2 | |
| SCHEMBL19220797 | 0.88 | HDAC3 (0.69) | EGFRKDRERBB2 | |
| SCHEMBL19220791 | 0.87 | EGFR (0.77) | RETEGFRKDRKIF5B | |
| SCHEMBL19220795 | 0.87 | HDAC3 (0.69) | EGFRKDRERBB2 | |
| SCHEMBL14066712 | 0.86 | HDAC3 (0.82) | EGFRKDRERBB2 | |
| SCHEMBL19220793 | 0.86 | EGFR (0.82) | RETEGFRKDRERBB2FLT4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023092094-A2 | BIFUNCTIONAL CHIMERIC MOLECULES FOR LABELING OF KINASES WITH TARGET BINDING MOIETIES AND METHODS OF USE THEREOF | THE BROAD INSTITUTE, INC. (US) | 2023-05-25 | — | — | WO | disclosed |