Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK13 | O15264 | 9/20 | 0.53 |
| ▸ | MAPK12 | P53778 | 9/20 | 0.53 |
| ▸ | MAPK11 | Q15759 | 9/20 | 0.53 |
| ▸ | MAPK14 | Q16539 | 9/20 | 0.53 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.41 |
| ▸ | MEN1 | O00255 | 3/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.39 |
| ▸ | LMNA | P02545 | 3/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 3/20 | 0.39 |
| ▸ | MAPT | P10636 | 2/20 | 0.39 |
| ▸ | HTT | P42858 | 2/20 | 0.39 |
| ▸ | PPARG | P37231 | 1/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | AURKA | O14965 | 1/20 | 0.37 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2198867 | 0.86 | MAPK14 (0.53) | MAPK13MAPK12MAPK11MAPK14SMN1; SMN2 | |
| SCHEMBL2197454 | 0.85 | MAPK14 (0.42) | MAPK13MAPK12MAPK11MAPK14MEN1 | |
| SCHEMBL2199334 | 0.85 | MAPK14 (0.48) | MAPK13MAPK12MAPK11MAPK14 | |
| SCHEMBL2198471 | 0.84 | MAPK14 (0.63) | MAPK13MAPK12MAPK11MAPK14MEN1 | |
| SCHEMBL2198875 | 0.78 | MAPK14 (0.53) | MAPK13MAPK12MAPK11MAPK14LMNA | |
| SCHEMBL2198996 | 0.77 | MAPK14 (0.64) | MAPK13MAPK12MAPK11MAPK14HPGD | |
| SCHEMBL2195134 | 0.77 | MAPK13 (0.70) | MAPK13MAPK12MAPK11MAPK14SMN1; SMN2 | |
| SCHEMBL2199744 | 0.76 | MAPK14 (0.50) | MAPK13MAPK12MAPK11MAPK14SMN1; SMN2 | |
| SCHEMBL2202231 | 0.75 | MAPK13 (0.50) | MAPK13MAPK12MAPK11MAPK14MEN1 | |
| SCHEMBL2198835 | 0.74 | MAPK13 (0.51) | MAPK13MAPK12MAPK11MAPK14SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1658263-B9 | NOVEL AMINOBENZOPHENONE COMPOUNDS | LEO PHARMA AS (DK) | 2011-11-09 | — | — | EP | disclosed |
| EP-1658263-B1 | NOVEL AMINOBENZOPHENONE COMPOUNDS | LEO PHARMA AS (DK) | 2010-06-02 | — | — | EP | disclosed |