Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE5A | O76074 | 20/20 | 0.58 |
| ▸ | PDE6C | P51160 | 2/20 | 0.51 |
| ▸ | PDE11A | Q9HCR9 | 2/20 | 0.51 |
| ▸ | PDE1A | P54750 | 1/20 | 0.51 |
| ▸ | PDE1B | Q01064 | 1/20 | 0.51 |
| ▸ | PDE1C | Q14123 | 1/20 | 0.51 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2565100 | 0.91 | PDE5A (0.57) | PDE5APDE6CPDE11APDE1APDE1B | |
| SCHEMBL2566101 | 0.90 | PDE5A (0.55) | PDE5APDE6CPDE11APDE1APDE1B | |
| SCHEMBL2565150 | 0.89 | PDE5A (0.62) | PDE5APDE6CPDE11APDE1APDE1B | |
| SCHEMBL2562786 | 0.87 | PDE5A (0.62) | PDE5APDE6CPDE11APDE1APDE1B | |
| SCHEMBL2567385 | 0.86 | PDE5A (0.60) | PDE5APDE6CPDE11APDE1APDE1B | |
| SCHEMBL2568065 | 0.85 | PDE5A (0.61) | PDE5APDE6CPDE11APDE1APDE1B | |
| SCHEMBL2568069 | 0.85 | PDE5A (0.55) | PDE5APDE6CPDE11APDE1APDE1B | |
| SCHEMBL16188306 | 0.85 | PDE5A (0.61) | PDE5APDE6CPDE11APDE1APDE1B | |
| SCHEMBL2562373 | 0.85 | PDE5A (0.64) | PDE5APDE6CPDE11APDE1APDE1B | |
| SCHEMBL2569264 | 0.85 | PDE5A (0.66) | PDE5APDE6CPDE11APDE1APDE1B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2383262-A1 | PHENYL PYRIMIDONE COMPOUNDS, PHARMACEUTICAL COMPOSITIONS, PREPARATION METHODS AND USES THEREOF | Topharman Shanghai Co., Ltd. (CN) | 2011-11-02 | — | — | EP | claimed |
| EP-2383262-B1 | PHENYL PYRIMIDONE COMPOUNDS, PHARMACEUTICAL COMPOSITIONS, PREPARATION METHODS AND USES THEREOF | TOPHARMAN SHANGHAI CO LTD (CN) | 2016-07-06 | — | — | EP | disclosed |
| EP-2383262-A1 | PHENYL PYRIMIDONE COMPOUNDS, PHARMACEUTICAL COMPOSITIONS, PREPARATION METHODS AND USES THEREOF | Topharman Shanghai Co., Ltd. (CN) | 2011-11-02 | — | — | EP | disclosed |