Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | S1PR1 | P21453 | 20/20 | 0.65 |
| ▸ | S1PR4 | O95977 | 2/20 | 0.57 |
| ▸ | S1PR5 | Q9H228 | 2/20 | 0.57 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.39 |
| ▸ | S1PR3 | Q99500 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2566565 | 0.86 | S1PR1 (0.71) | S1PR1S1PR4S1PR5S1PR3 | |
| SCHEMBL2565078 | 0.85 | S1PR1 (0.77) | S1PR1S1PR4S1PR5ADORA3 | |
| SCHEMBL13809362 | 0.82 | S1PR1 (0.71) | S1PR1S1PR4S1PR5ADORA3 | |
| SCHEMBL2566613 | 0.82 | S1PR1 (0.71) | S1PR1S1PR4S1PR5ADORA3 | |
| SCHEMBL2565071 | 0.82 | S1PR1 (0.75) | S1PR1S1PR4S1PR5ADORA3 | |
| SCHEMBL2565151 | 0.82 | S1PR1 (0.72) | S1PR1S1PR4S1PR5ADORA3 | |
| SCHEMBL2565208 | 0.81 | S1PR1 (0.77) | S1PR1S1PR4S1PR5 | |
| SCHEMBL2566552 | 0.81 | S1PR1 (0.79) | S1PR1S1PR4S1PR5ADORA3 | |
| SCHEMBL2561750 | 0.81 | S1PR1 (0.74) | S1PR1S1PR4S1PR5 | |
| SCHEMBL13809356 | 0.81 | S1PR1 (0.77) | S1PR1S1PR4S1PR5ADORA3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2222668-B1 | TETRAHYDROCYCLOPENTA[B]INDOL-3-YL CARBOXYLIC ACID DERIVATIVES USEFUL IN THE TREATMENT OF AUTOIMMUNE AND INFLAMMATORY DISORDERS | ARENA PHARM INC (US) | 2011-11-02 | — | — | EP | disclosed |