SCHEMBL2571375

SCHEMBL2571375

COc1ccc2c(c1C)Oc1ccc(Br)cc1C21N=C(N)N(C)C1=O

nearest known ligand 0.51

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
BACE1 P56817 20/20 0.51
CTSD P07339 2/20 0.45

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL2576040 0.84 BACE1 (0.71) BACE1CTSD
SCHEMBL2574295 0.83 BACE1 (0.61) BACE1CTSD
SCHEMBL2577607 0.82 BACE1 (0.73) BACE1CTSD
SCHEMBL2573862 0.81 BACE1 (0.70) BACE1CTSD
SCHEMBL2574562 0.81 BACE1 (0.57) BACE1CTSD
SCHEMBL2573818 0.80 BACE1 (0.65) BACE1CTSD
SCHEMBL2575414 0.79 BACE1 (0.55) BACE1CTSD
SCHEMBL4507469 0.78 BACE1 (0.73) BACE1CTSD
SCHEMBL2573405 0.78 BACE1 (0.58) BACE1CTSD
Formic Acid SCHEMBL2560041 0.77 BACE1 (0.58) BACE1CTSD

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2011130741-A1 COMPOUNDS FOR TREATING NEURODEGENERATIVE DISEASES ARRAY BIOPHARMA INC. (US) 2011-10-20 WO disclosed