Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | METAP2 | P50579 | 1/20 | 0.42 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.36 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.36 |
| ▸ | CHRNB4 | P30926 | 1/20 | 0.35 |
| ▸ | CHRNA3 | P32297 | 1/20 | 0.35 |
| ▸ | USP30 | Q70CQ3 | 2/20 | 0.34 |
| ▸ | HSD17B2 | P37059 | 2/20 | 0.34 |
| ▸ | APP | P05067 | 1/20 | 0.34 |
| ▸ | BRD4 | O60885 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 3/20 | 0.33 |
| ▸ | HSD17B1 | P14061 | 1/20 | 0.33 |
| ▸ | PHGDH | O43175 | 1/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
| ▸ | RAB9A | P51151 | 1/20 | 0.33 |
| ▸ | ESRRA | P11474 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23402778 | 0.81 | NPC1 (0.49) | METAP2MAPTPOLBRAB9AESRRA | |
| SCHEMBL16667664 | 0.80 | CYP11B1 (0.50) | CYP11B1HSD11B1MAPTPHGDHPOLB | |
| SCHEMBL16664764 | 0.80 | IDO1 (0.44) | MAPTRAB9A | |
| SCHEMBL17295620 | 0.80 | IDO1 (0.44) | MAPTRAB9A | |
| SCHEMBL25645955 | 0.80 | ESR2 (0.44) | MAPTRAB9A | |
| SCHEMBL8843320 | 0.78 | PHGDH (0.47) | PHGDH | |
| SCHEMBL25646028 | 0.78 | IDO1 (0.48) | CYP11B1HSD11B1BRD4POLB | |
| SCHEMBL17295149 | 0.78 | IDO1 (0.44) | CYP11B1HSD11B1USP30HSD17B2MAPT | |
| SCHEMBL17290741 | 0.78 | IDO1 (0.44) | CYP11B1HSD11B1USP30HSD17B2MAPT | |
| SCHEMBL17290745 | 0.76 | KDM4E (0.49) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023107592-A1 | PYRIDOPYRIMIDINES AND METHODS OF THEIR USE | Kineta, Inc. (US) | 2023-06-15 | — | — | WO | disclosed |