Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNH2 | Q12809 | 3/20 | 0.55 |
| ▸ | HRH4 | Q9H3N8 | 3/20 | 0.55 |
| ▸ | HRH3 | Q9Y5N1 | 3/20 | 0.55 |
| ▸ | HRH2 | P25021 | 2/20 | 0.49 |
| ▸ | HRH1 | P35367 | 2/20 | 0.49 |
| ▸ | PIK3CA | P42336 | 12/20 | 0.41 |
| ▸ | LMNA | P02545 | 3/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | PIK3CD | O00329 | 8/20 | 0.39 |
| ▸ | PIK3CG | P48736 | 7/20 | 0.39 |
| ▸ | MTOR | P42345 | 5/20 | 0.39 |
| ▸ | NUDT1 | P36639 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.36 |
| ▸ | PIK3R1 | P27986 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16919692 | 0.82 | KCNH2 (0.55) | KCNH2HRH4HRH3HRH2HRH1 | |
| SCHEMBL25277503 | 0.81 | PIK3CA (0.46) | PIK3CALMNAALDH1A1SMN1; SMN2GAA | |
| SCHEMBL16919667 | 0.78 | PIK3CA (0.55) | KCNH2HRH4HRH3PIK3CALMNA | |
| SCHEMBL25223154 | 0.76 | GAK (0.56) | HRH4HRH3HRH1PIK3CALMNA | |
| SCHEMBL19445263 | 0.75 | PIK3CA (0.61) | KCNH2HRH4HRH3PIK3CALMNA | |
| SCHEMBL25277910 | 0.74 | PIK3CD (0.61) | PIK3CAPIK3CDPIK3CGMTORPIK3R1 | |
| SCHEMBL19445264 | 0.73 | PIK3CA (0.53) | KCNH2HRH4HRH3PIK3CAALDH1A1 | |
| SCHEMBL25231114 | 0.71 | STAT3 (0.49) | PIK3CAMTOR | |
| SCHEMBL27275652 | 0.71 | PIK3CA (0.38) | PIK3CALMNAALDH1A1SMN1; SMN2PIK3CD | |
| SCHEMBL16919689 | 0.71 | PIK3CA (0.52) | KCNH2HRH4HRH3PIK3CAALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023107592-A1 | PYRIDOPYRIMIDINES AND METHODS OF THEIR USE | Kineta, Inc. (US) | 2023-06-15 | — | — | WO | disclosed |