Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM5 | P41594 | 9/20 | 0.52 |
| ▸ | GRM1 | Q13255 | 9/20 | 0.52 |
| ▸ | PDK4 | Q16654 | 1/20 | 0.52 |
| ▸ | PDE10A | Q9Y233 | 2/20 | 0.51 |
| ▸ | JAK1 | P23458 | 1/20 | 0.47 |
| ▸ | CNR1 | P21554 | 1/20 | 0.47 |
| ▸ | GABRP | O00591 | 1/20 | 0.47 |
| ▸ | GABRD | O14764 | 1/20 | 0.47 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.47 |
| ▸ | GABRB1 | P18505 | 1/20 | 0.47 |
| ▸ | GABRG2 | P18507 | 1/20 | 0.47 |
| ▸ | GABRB3 | P28472 | 1/20 | 0.47 |
| ▸ | GABRA5 | P31644 | 1/20 | 0.47 |
| ▸ | GABRA3 | P34903 | 1/20 | 0.47 |
| ▸ | GABRA2 | P47869 | 1/20 | 0.47 |
| ▸ | GABRB2 | P47870 | 1/20 | 0.47 |
| ▸ | GABRA4 | P48169 | 1/20 | 0.47 |
| ▸ | GABRE | P78334 | 1/20 | 0.47 |
| ▸ | GABRA6 | Q16445 | 1/20 | 0.47 |
| ▸ | GABRG1 | Q8N1C3 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17655532 | 0.82 | PDK4 (0.61) | GRM5GRM1PDK4PDE10AHTR6 | |
| SCHEMBL14591413 | 0.81 | PDK4 (0.61) | GRM5GRM1PDK4PDE10AJAK1 | |
| SCHEMBL19297054 | 0.81 | PDK4 (0.60) | GRM5GRM1PDK4PDE10AJAK1 | |
| SCHEMBL29455068 | 0.80 | GRM1 (0.53) | GRM5GRM1PDK4PDE10AJAK1 | |
| SCHEMBL4001532 | 0.80 | GRM5 (0.63) | GRM5GRM1PDK4PDE10ATNK2 | |
| SCHEMBL30676170 | 0.79 | GRM5 (0.61) | GRM5GRM1PDK4PDE10AHTR6 | |
| SCHEMBL2631187 | 0.79 | GRM5 (0.61) | GRM5GRM1PDK4PDE10AHTR6 | |
| SCHEMBL15951022 | 0.79 | PDK4 (0.60) | GRM5GRM1PDK4PDE10ACNR1 | |
| SCHEMBL23716616 | 0.79 | GRM5 (0.53) | GRM5GRM1PDK4PDE10AJAK1 | |
| SCHEMBL29895681 | 0.79 | GRM5 (0.53) | GRM5GRM1PDK4PDE10AJAK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230183237-A1 | COMPETITIVE AND NONCOMPETITIVE INHIBITORS OF THE MUSCARINIC ACETYLCHOLINE RECEPTOR M5 | VANDERBILT UNIVERSITY | 2023-06-15 | — | — | US | disclosed |
| US-20230183237-A1 | COMPETITIVE AND NONCOMPETITIVE INHIBITORS OF THE MUSCARINIC ACETYLCHOLINE RECEPTOR M5 | VANDERBILT UNIVERSITY | 2023-06-15 | — | — | US | disclosed |
| CN-115667273-A | Competitive and non-competitive inhibitors of muscarinic acetylcholine receptor M5 | 范德堡大学 | 2023-01-31 | — | — | CN | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230183237-A1 | COMPETITIVE AND NONCOMPETITIVE INHIBITORS OF THE MUSCARINIC ACETYLCHOLINE RECEPTOR M5 | CHRM5, CHRM1, CHRM2 | GRM5 21/4885GRM1 30/4885PDK4 3127/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.