Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACE | P12821 | 2/20 | 0.51 |
| ▸ | NAMPT | P43490 | 2/20 | 0.45 |
| ▸ | HPGD | P15428 | 1/20 | 0.43 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.43 |
| ▸ | ESR1 | P03372 | 1/20 | 0.43 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.43 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.42 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.41 |
| ▸ | BCL2 | P10415 | 1/20 | 0.40 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.40 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.40 |
| ▸ | ABHD6 | Q9BV23 | 1/20 | 0.40 |
| ▸ | SYK | P43405 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25591220 | 0.94 | ACE (0.51) | ACENAMPTHPGDNOTUMESR1 | |
| SCHEMBL25591466 | 0.91 | ACE (0.43) | ACENAMPTHPGDNOTUMHRH3 | |
| SCHEMBL25730373 | 0.88 | NAMPT (0.56) | NAMPT | |
| SCHEMBL25591467 | 0.86 | HDAC6 (0.44) | ACENAMPTHRH3 | |
| SCHEMBL6188423 | 0.83 | NOTUM (0.63) | ACEHPGDNOTUMESR1ESR2 | |
| SCHEMBL25589675 | 0.82 | KMT2A (0.50) | ACENAMPTHPGDNOTUMESR1 | |
| SCHEMBL13595549 | 0.80 | HPGD (0.60) | HPGDNOTUMESR1ESR2HRH3 | |
| SCHEMBL12783352 | 0.80 | ACE (0.70) | ACENAMPTHPGDNOTUMHRH3 | |
| SCHEMBL26763813 | 0.79 | DPP7 (0.56) | NOTUMESR1ESR2 | |
| SCHEMBL6962531 | 0.77 | NR1H2 (0.54) | ACENAMPTHPGDNOTUMESR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023094827-A1 | SPIROCYCLIC CAV2.3 ANTAGONISTS | LARIO THERAPEUTICS LIMITED (GB) | 2023-06-01 | — | — | WO | disclosed |