Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IKZF2 | Q9UKS7 | 12/20 | 0.60 |
| ▸ | CRBN | Q96SW2 | 8/20 | 0.55 |
| ▸ | GSPT1 | P15170 | 2/20 | 0.55 |
| ▸ | DDB1 | Q16531 | 2/20 | 0.55 |
| ▸ | IKZF3 | Q9UKT9 | 1/20 | 0.55 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.54 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.54 |
| ▸ | CSNK1A1 | P48729 | 1/20 | 0.49 |
| ▸ | IKZF1 | Q13422 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25741130 | 1.00 | IKZF2 (0.60) | IKZF2CRBNGSPT1DDB1IKZF3 | |
| SCHEMBL25741079 | 0.90 | CRBN (0.58) | IKZF2CRBNGSPT1DDB1IKZF3 | |
| SCHEMBL25741082 | 0.90 | CRBN (0.58) | IKZF2CRBNGSPT1DDB1IKZF3 | |
| SCHEMBL25741131 | 0.89 | CRBN (0.55) | IKZF2CRBNGSPT1DDB1IKZF3 | |
| SCHEMBL25742046 | 0.89 | CRBN (0.59) | IKZF2CRBNGSPT1DDB1IKZF3 | |
| SCHEMBL25741056 | 0.88 | IKZF2 (0.64) | IKZF2CRBNGSPT1DDB1IKZF3 | |
| SCHEMBL25741055 | 0.88 | IKZF2 (0.61) | IKZF2CRBNGSPT1DDB1IKZF3 | |
| SCHEMBL25741152 | 0.88 | CRBN (0.57) | IKZF2CRBNGSPT1DDB1IKZF3 | |
| SCHEMBL25741133 | 0.88 | IKZF2 (0.57) | IKZF2CRBNGSPT1DDB1IKZF3 | |
| SCHEMBL25242257 | 0.88 | IKZF2 (0.63) | IKZF2CRBNGSPT1DDB1IKZF3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023122581-A2 | IKAROS ZINC FINGER FAMILY DEGRADERS AND USES THEREOF | GILEAD SCIENCES, INC. (US) | 2023-06-29 | — | — | WO | disclosed |