SCHEMBL25741237 — predicted protein targets

Predicted protein targets (top 8)

	gene	UniProt	supporting neighbours	confidence
▸	CRBN	Q96SW2	10/20	0.57

▸	GSPT1	P15170	2/20	0.57

▸	DDB1	Q16531	2/20	0.57

▸	IKZF3	Q9UKT9	1/20	0.57

▸	IKZF2	Q9UKS7	10/20	0.56

▸	CYP2C19	P33261	1/20	0.56

▸	KCNH2	Q12809	1/20	0.56

▸	CSNK1A1	P48729	1/20	0.50

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compound	similarity	top predicted	shared targets
SCHEMBL25741049	0.91	CRBN (0.58)	CRBNGSPT1DDB1IKZF3IKZF2
SCHEMBL25741223	0.90	CRBN (0.58)	CRBNGSPT1DDB1IKZF3IKZF2
SCHEMBL25741056	0.90	IKZF2 (0.64)	CRBNGSPT1DDB1IKZF3IKZF2
SCHEMBL25741055	0.90	IKZF2 (0.61)	CRBNGSPT1DDB1IKZF3IKZF2
SCHEMBL25741053	0.90	IKZF2 (0.57)	CRBNGSPT1DDB1IKZF3IKZF2
SCHEMBL25741043	0.90	IKZF2 (0.57)	CRBNGSPT1DDB1IKZF3IKZF2
SCHEMBL25741082	0.89	CRBN (0.58)	CRBNGSPT1DDB1IKZF3IKZF2
SCHEMBL25741079	0.89	CRBN (0.58)	CRBNGSPT1DDB1IKZF3IKZF2
SCHEMBL25242257	0.89	IKZF2 (0.63)	CRBNGSPT1DDB1IKZF3IKZF2
SCHEMBL25742229	0.89	IKZF2 (0.55)	CRBNGSPT1DDB1IKZF3IKZF2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

Patent	Title	Assignee	Published	Priority	Filing	Country	Status
WO-2023122581-A2	IKAROS ZINC FINGER FAMILY DEGRADERS AND USES THEREOF	GILEAD SCIENCES, INC. (US)	2023-06-29	—	—	WO	disclosed