Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BACE1 | P56817 | 20/20 | 0.62 |
| ▸ | BACE2 | Q9Y5Z0 | 3/20 | 0.44 |
| ▸ | CTSD | P07339 | 3/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7713176 | 0.89 | BACE1 (0.49) | BACE1BACE2CTSD | |
| SCHEMBL7707977 | 0.87 | BACE1 (0.52) | BACE1BACE2CTSD | |
| SCHEMBL7711171 | 0.81 | BACE1 (0.55) | BACE1BACE2CTSD | |
| SCHEMBL2573862 | 0.81 | BACE1 (0.70) | BACE1BACE2CTSD | |
| SCHEMBL7704748 | 0.80 | BACE1 (0.56) | BACE1BACE2 | |
| SCHEMBL7711676 | 0.78 | BACE1 (0.78) | BACE1BACE2CTSD | |
| SCHEMBL7711751 | 0.78 | BACE1 (0.52) | BACE1BACE2CTSD | |
| SCHEMBL16487873 | 0.77 | BACE1 (1.00) | BACE1BACE2CTSD | |
| SCHEMBL8533444 | 0.77 | BACE1 (1.00) | BACE1BACE2CTSD | |
| SCHEMBL2571649 | 0.77 | BACE1 (1.00) | BACE1BACE2CTSD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011130741-A1 | COMPOUNDS FOR TREATING NEURODEGENERATIVE DISEASES | ARRAY BIOPHARMA INC. (US) | 2011-10-20 | — | — | WO | disclosed |
| WO-2011130741-A1 | COMPOUNDS FOR TREATING NEURODEGENERATIVE DISEASES | ARRAY BIOPHARMA INC. (US) | 2011-10-20 | — | — | WO | disclosed |