Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAP3K12 | Q12852 | 8/20 | 0.39 |
| ▸ | PIK3CA | P42336 | 9/20 | 0.36 |
| ▸ | MTOR | P42345 | 8/20 | 0.36 |
| ▸ | SRC | P12931 | 5/20 | 0.36 |
| ▸ | PIK3CD | O00329 | 5/20 | 0.36 |
| ▸ | PIK3CB | P42338 | 5/20 | 0.36 |
| ▸ | PIK3CG | P48736 | 5/20 | 0.36 |
| ▸ | ABL1 | P00519 | 4/20 | 0.36 |
| ▸ | EGFR | P00533 | 4/20 | 0.36 |
| ▸ | HCK | P08631 | 4/20 | 0.36 |
| ▸ | KDR | P35968 | 4/20 | 0.36 |
| ▸ | EPHB4 | P54760 | 4/20 | 0.36 |
| ▸ | PRKDC | P78527 | 4/20 | 0.36 |
| ▸ | PI4KB | Q9UBF8 | 4/20 | 0.36 |
| ▸ | CNR2 | P34972 | 2/20 | 0.33 |
| ▸ | PIK3C3 | Q8NEB9 | 1/20 | 0.32 |
| ▸ | RPTOR | Q8N122 | 1/20 | 0.31 |
| ▸ | MLST8 | Q9BVC4 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25746248 | 1.00 | MAP3K12 (0.39) | MAP3K12PIK3CAMTORSRCPIK3CD | |
| SCHEMBL24007683 | 0.89 | MAP3K12 (0.39) | MAP3K12PIK3CAMTORSRCPIK3CD | |
| SCHEMBL24007360 | 0.89 | MAP3K12 (0.39) | MAP3K12PIK3CAMTORSRCPIK3CD | |
| SCHEMBL27193361 | 0.89 | MAP3K12 (0.42) | MAP3K12PIK3CAMTORSRCPIK3CD | |
| SCHEMBL24567236 | 0.89 | MAP3K12 (0.42) | MAP3K12PIK3CAMTORSRCPIK3CD | |
| SCHEMBL27193654 | 0.89 | MAP3K12 (0.42) | MAP3K12PIK3CAMTORSRCPIK3CD | |
| SCHEMBL24815073 | 0.89 | CNR2 (0.36) | MAP3K12PIK3CAMTORSRCPIK3CD | |
| SCHEMBL24007026 | 0.89 | CNR2 (0.36) | MAP3K12PIK3CAMTORSRCPIK3CD | |
| SCHEMBL24007277 | 0.89 | CNR2 (0.36) | MAP3K12PIK3CAMTORSRCPIK3CD | |
| SCHEMBL26012663 | 0.83 | CNR2 (0.35) | MAP3K12PIK3CAMTORSRCPIK3CD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230265075-A1 | 6-HETEROARYLOXY BENZIMIDAZOLES AND AZABENZIMIDAZOLES AS JAK2 INHIBITORS | AJAX THERAPEUTICS, INC. | 2023-08-24 | — | — | US | disclosed |
| US-11691963-B2 | 6-heteroaryloxy benzimidazoles and azabenzimidazoles as JAK2 inhibitors | AJAX THERAPEUTICS, INC. (US) | 2023-07-04 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230265075-A1 | 6-HETEROARYLOXY BENZIMIDAZOLES AND AZABENZIMIDAZOLES AS JAK2 INHIBITORS | JAK2, JAK3, STAT5B | MAP3K12 516/4885PIK3CA 147/4885MTOR 404/4885 |
| US-11691963-B2 | 6-heteroaryloxy benzimidazoles and azabenzimidazoles as JAK2 inhibitors | JAK2, JAK3, STAT5B | MAP3K12 516/4885PIK3CA 147/4885MTOR 404/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.