Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DPP4 | P27487 | 6/20 | 0.57 |
| ▸ | AKT1 | P31749 | 1/20 | 0.54 |
| ▸ | AKT2 | P31751 | 1/20 | 0.54 |
| ▸ | AKT3 | Q9Y243 | 1/20 | 0.54 |
| ▸ | FAP | Q12884 | 4/20 | 0.53 |
| ▸ | DPP8 | Q6V1X1 | 4/20 | 0.53 |
| ▸ | DPP9 | Q86TI2 | 4/20 | 0.53 |
| ▸ | DPP7 | Q9UHL4 | 4/20 | 0.53 |
| ▸ | HRH1 | P35367 | 3/20 | 0.51 |
| ▸ | HRH2 | P25021 | 2/20 | 0.51 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.51 |
| ▸ | TSHR | P16473 | 1/20 | 0.47 |
| ▸ | GAA | P10253 | 1/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.45 |
| ▸ | HTR1A | P08908 | 1/20 | 0.45 |
| ▸ | DRD4 | P21917 | 1/20 | 0.45 |
| ▸ | HTR2A | P28223 | 1/20 | 0.45 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.45 |
| ▸ | LMNA | P02545 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7029548 | 1.00 | DPP4 (0.57) | DPP4AKT1AKT2AKT3FAP | |
| Hydrochloric Acid SCHEMBL2574968 | 0.99 | DPP4 (0.56) | DPP4AKT1AKT2AKT3FAP | |
| Hydrochloric Acid SCHEMBL2574972 | 0.99 | DPP4 (0.56) | DPP4AKT1AKT2AKT3FAP | |
| SCHEMBL9994557 | 0.89 | DPP4 (0.58) | DPP4AKT1AKT2AKT3FAP | |
| Hydrochloric Acid SCHEMBL9994554 | 0.88 | DPP4 (0.57) | DPP4AKT1AKT2AKT3FAP | |
| Hydrochloric Acid SCHEMBL9994561 | 0.88 | DPP4 (0.57) | DPP4AKT1AKT2AKT3FAP | |
| SCHEMBL8485011 | 0.86 | DPP4 (0.61) | DPP4AKT1AKT2AKT3FAP | |
| SCHEMBL12618900 | 0.86 | DPP7 (0.56) | DPP4AKT1AKT2AKT3FAP | |
| SCHEMBL13456371 | 0.86 | DPP7 (0.56) | DPP4AKT1AKT2AKT3FAP | |
| SCHEMBL8488107 | 0.86 | DPP4 (0.63) | DPP4AKT1AKT2AKT3FAP |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8048881-B2 | Uding 4-aminocarbonyl-pyrimidine; vascular disorders; cardiovascular disorders; thrombosis; brain disorders; vision defects | ACTELION PHARMACEUTICALS LTD. (CH) | 2011-11-01 | — | — | US | disclosed |
| US-20080194576-A1 | Pyrimidine Derivatives and Their Use as P2Y12 Receptor Antagonists | ACTELION PHARMACEUTICALS LTD. (CH) | 2008-08-14 | — | — | US | disclosed |
| EP-1893634-A2 | PYRIMIDINE DERIVATIVES AND THEIR USE AS P2Y12 RECEPTOR ANTAGONISTS | Actelion Pharmaceuticals Ltd. (CH) | 2008-03-05 | — | — | EP | disclosed |
| WO-2006114774-A2 | PYRIMIDINE DERIVATIVES AND THEIR USE AS P2Y12 RECEPTOR ANTAGONISTS | ACTELION PHARMACEUTICALS LTD (CH) | 2006-11-02 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080194576-A1 | Pyrimidine Derivatives and Their Use as P2Y12 Receptor Antagonists | P2RY12, P2RY13, P2RY4 | DPP4 184/4885AKT1 2275/4885AKT2 2353/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.