Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH4 | Q9H3N8 | 15/20 | 0.71 |
| ▸ | HRH3 | Q9Y5N1 | 5/20 | 0.59 |
| ▸ | CXCR4 | P61073 | 1/20 | 0.46 |
| ▸ | OGA | O60502 | 3/20 | 0.45 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.44 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.44 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.44 |
| ▸ | HRH2 | P25021 | 1/20 | 0.44 |
| ▸ | HTR1D | P28221 | 1/20 | 0.44 |
| ▸ | HTR2A | P28223 | 1/20 | 0.44 |
| ▸ | HTR2C | P28335 | 1/20 | 0.44 |
| ▸ | HTR7 | P34969 | 1/20 | 0.44 |
| ▸ | HTR2B | P41595 | 1/20 | 0.44 |
| ▸ | HTR5A | P47898 | 1/20 | 0.44 |
| ▸ | HTR6 | P50406 | 1/20 | 0.44 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.44 |
| ▸ | TMEM97 | Q5BJF2 | 1/20 | 0.44 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1588650 | 0.83 | HRH4 (1.00) | HRH4HRH3CXCR4OGAADRA2B | |
| SCHEMBL605069 | 0.80 | HRH4 (0.68) | HRH4HRH3OGA | |
| SCHEMBL605070 | 0.80 | HRH4 (0.68) | HRH4HRH3OGA | |
| SCHEMBL1588619 | 0.80 | HRH4 (0.67) | HRH4HRH3CXCR4OGAADRA2B | |
| SCHEMBL602710 | 0.79 | HRH4 (0.76) | HRH4HRH3 | |
| SCHEMBL602711 | 0.79 | HRH4 (0.76) | HRH4HRH3 | |
| SCHEMBL859700 | 0.79 | HRH4 (0.72) | HRH4HRH3CXCR4OGA | |
| SCHEMBL29935697 | 0.79 | HRH4 (0.72) | HRH4HRH3CXCR4OGA | |
| SCHEMBL846581 | 0.78 | HRH4 (0.74) | HRH4HRH3CXCR4OGAADRA2B | |
| SCHEMBL1588024 | 0.78 | HRH4 (1.00) | HRH4HRH3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2382013-A1 | SELECTIVE HISTAMINE H4 RECEPTOR ANTAGONISTS FOR THE TREATMENT OF VESTIBULAR DISORDERS. | INSERM (Institut National de la Santé et de la Recherche Médicale) (FR) | 2011-11-02 | — | — | EP | disclosed |
| WO-2010072829-A1 | SELECTIVE HISTAMINE H4 RECEPTOR ANTAGONISTS FOR THE TREATMENT OF VESTIBULAR DISORDERS. | INSERM (Institut National de la Santé et de la Recherche Médicale) (FR) | 2010-07-01 | — | — | WO | disclosed |