Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE10A | Q9Y233 | 3/20 | 0.51 |
| ▸ | PDE4A | P27815 | 1/20 | 0.40 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.40 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.40 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.40 |
| ▸ | HTR2A | P28223 | 1/20 | 0.32 |
| ▸ | HTR2C | P28335 | 1/20 | 0.32 |
| ▸ | HTR2B | P41595 | 1/20 | 0.32 |
| ▸ | CYP19A1 | P11511 | 3/20 | 0.32 |
| ▸ | CYP11B1 | P15538 | 3/20 | 0.32 |
| ▸ | CYP11B2 | P19099 | 3/20 | 0.32 |
| ▸ | CYP17A1 | P05093 | 1/20 | 0.32 |
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.31 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.30 |
| ▸ | HCRTR2 | O43614 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2563116 | 0.88 | PDE10A (0.59) | PDE10APDE4APDE4BPDE4CPDE4D | |
| SCHEMBL2563558 | 0.87 | PDE10A (0.55) | PDE10APDE4APDE4BPDE4CPDE4D | |
| SCHEMBL2563663 | 0.87 | PDE10A (0.53) | PDE10APDE4APDE4BPDE4CPDE4D | |
| SCHEMBL2557009 | 0.87 | PDE10A (0.55) | PDE10APDE4APDE4BPDE4CPDE4D | |
| SCHEMBL2563691 | 0.86 | PDE10A (0.55) | PDE10APDE4APDE4BPDE4CPDE4D | |
| SCHEMBL2553791 | 0.86 | PDE10A (0.52) | PDE10APDE4APDE4BPDE4CPDE4D | |
| SCHEMBL2563284 | 0.85 | PDE10A (0.56) | PDE10APDE4APDE4BPDE4CPDE4D | |
| SCHEMBL2557842 | 0.85 | PDE10A (0.51) | PDE10APDE4APDE4BPDE4CPDE4D | |
| SCHEMBL2561222 | 0.85 | PDE10A (0.51) | PDE10APDE4APDE4BPDE4CPDE4D | |
| SCHEMBL2586394 | 0.85 | PDE10A (0.56) | PDE10APDE4APDE4BPDE4CPDE4D |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011132051-A2 | TRICYCLE COMPOUNDS AS PHOSPHODIESTERASE-10 INHIBITORS | GLENMARK PHARMACEUTICALS S.A. (CH) | 2011-10-27 | — | — | WO | claimed |