Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KIT | P10721 | 7/20 | 0.37 |
| ▸ | BMPR1B | O00238 | 1/20 | 0.32 |
| ▸ | BMPR1A | P36894 | 1/20 | 0.32 |
| ▸ | TGFBR1 | P36897 | 1/20 | 0.32 |
| ▸ | ACVRL1 | P37023 | 1/20 | 0.32 |
| ▸ | ACVR1 | Q04771 | 1/20 | 0.32 |
| ▸ | PARP1 | P09874 | 2/20 | 0.31 |
| ▸ | ESR1 | P03372 | 1/20 | 0.31 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.31 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.31 |
| ▸ | RET | P07949 | 3/20 | 0.31 |
| ▸ | PARP2 | Q9UGN5 | 1/20 | 0.30 |
| ▸ | MC4R | P32245 | 1/20 | 0.30 |
| ▸ | TLR9 | Q9NR96 | 1/20 | 0.30 |
| ▸ | TLR8 | Q9NR97 | 1/20 | 0.30 |
| ▸ | TLR7 | Q9NYK1 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25777898 | 0.86 | KIT (0.37) | KITRET | |
| SCHEMBL19459170 | 0.84 | MC4R (0.40) | KITRETMC4R | |
| SCHEMBL19459081 | 0.84 | RET (0.41) | KITTGFBR1ACVR1RETMC4R | |
| SCHEMBL19486399 | 0.84 | KIT (0.37) | KITBMPR1BBMPR1ATGFBR1ACVRL1 | |
| SCHEMBL21679943 | 0.83 | KIT (0.40) | KITRET | |
| SCHEMBL19481733 | 0.81 | JAK1 (0.42) | KITRETMC4R | |
| SCHEMBL19459128 | 0.81 | RET (0.49) | KITRET | |
| SCHEMBL25778277 | 0.81 | TLR9 (0.39) | KITPARP1TLR9TLR8TLR7 | |
| SCHEMBL25772331 | 0.80 | KIT (0.36) | KITBMPR1BBMPR1ATGFBR1ACVRL1 | |
| SCHEMBL25777745 | 0.80 | DRD3 (0.41) | KITRET |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3442977-B1 | INHIBITORS OF ACTIVIN RECEPTOR-LIKE KINASE | BLUEPRINT MEDICINES CORP (US) | 2023-06-28 | — | — | EP | disclosed |