Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CD | O00329 | 18/20 | 0.64 |
| ▸ | PIK3CA | P42336 | 8/20 | 0.55 |
| ▸ | PIK3R1 | P27986 | 1/20 | 0.55 |
| ▸ | PIK3CB | P42338 | 5/20 | 0.48 |
| ▸ | PIK3CG | P48736 | 5/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31614746 | 0.88 | PIK3CA (0.73) | PIK3CDPIK3CAPIK3R1PIK3CBPIK3CG | |
| SCHEMBL14257549 | 0.86 | PIK3CD (0.71) | PIK3CDPIK3CAPIK3R1 | |
| SCHEMBL190063 | 0.81 | PIK3CA (0.58) | PIK3CDPIK3CAPIK3R1PIK3CBPIK3CG | |
| SCHEMBL2674814 | 0.78 | PIK3CD (1.00) | PIK3CDPIK3CAPIK3CBPIK3CG | |
| SCHEMBL191085 | 0.76 | PIK3CA (0.79) | PIK3CDPIK3CAPIK3R1PIK3CBPIK3CG | |
| SCHEMBL190336 | 0.73 | PIK3CD (0.86) | PIK3CDPIK3CAPIK3R1PIK3CBPIK3CG | |
| SCHEMBL2739067 | 0.72 | PIK3CA (0.74) | PIK3CDPIK3CAPIK3R1PIK3CBPIK3CG | |
| SCHEMBL190242 | 0.72 | PIK3CD (0.73) | PIK3CDPIK3CAPIK3R1PIK3CBPIK3CG | |
| SCHEMBL1680075 | 0.71 | PIK3CD (0.79) | PIK3CDPIK3CAPIK3R1PIK3CBPIK3CG | |
| SCHEMBL2573412 | 0.70 | PIK3CD (0.58) | PIK3CDPIK3CAPIK3CB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2041139-B1 | PHARMACEUTICAL COMPOUNDS | HOFFMANN LA ROCHE (CH) | 2011-11-09 | — | — | EP | disclosed |