⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8502640 | 0.80 | — | — | |
| SCHEMBL22849475 | 0.76 | — | — | |
| SCHEMBL19267208 | 0.76 | — | — | |
| SCHEMBL19267216 | 0.76 | — | — | |
| SCHEMBL855934 | 0.76 | — | — | |
| SCHEMBL8041258 | 0.76 | — | — | |
| SCHEMBL28157085 | 0.74 | — | — | |
| SCHEMBL7743617 | 0.74 | — | — | |
| SCHEMBL16406106 | 0.73 | CYP3A4 (0.34) | — | |
| SCHEMBL1646778 | 0.71 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2593102-B1 | OXAZOLE DERIVATIVES USEFUL AS MODULATORS OF FAAH | MERCK SHARP & DOHME (US) | 2017-06-07 | — | — | EP | disclosed |
| US-9073879-B2 | Oxazole derivatives useful as modulators of FAAH | MERCK SHARP & DOHME CORP. (US) | 2015-07-07 | — | — | US | disclosed |
| EP-2593102-A1 | OXAZOLE DERIVATIVES USEFUL AS MODULATORS OF FAAH | Merck Sharp & Dohme Corp. (US) | 2013-05-22 | — | — | EP | disclosed |
| US-20130012526-A1 | OXAZOLE DERIVATIVES USEFUL AS MODULATORS OF FAAH | MERCK SHARP & DOHME CORP. (US) | 2013-01-10 | — | — | US | disclosed |
| WO-2011133447-A1 | OXAZOLE DERIVATIVES USEFUL AS MODULATORS OF FAAH | MERCK SHARP & DOHME CORP. (US) | 2011-10-27 | — | — | WO | disclosed |