Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BAD | Q92934 | 16/20 | 0.40 |
| ▸ | BCL2L1 | Q07817 | 14/20 | 0.40 |
| ▸ | BCL2 | P10415 | 7/20 | 0.40 |
| ▸ | MCL1 | Q07820 | 3/20 | 0.37 |
| ▸ | PMAIP1 | Q13794 | 2/20 | 0.37 |
| ▸ | MARK3 | P27448 | 2/20 | 0.35 |
| ▸ | GSK3B | P49841 | 2/20 | 0.35 |
| ▸ | CAMK2B | Q13554 | 2/20 | 0.35 |
| ▸ | MARK2 | Q7KZI7 | 2/20 | 0.35 |
| ▸ | MINK1 | Q8N4C8 | 2/20 | 0.35 |
| ▸ | SRPK1 | Q96SB4 | 2/20 | 0.35 |
| ▸ | HIPK2 | Q9H2X6 | 2/20 | 0.35 |
| ▸ | CDC7 | O00311 | 1/20 | 0.35 |
| ▸ | EEF2K | O00418 | 1/20 | 0.35 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.35 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.35 |
| ▸ | PAK4 | O96013 | 1/20 | 0.35 |
| ▸ | RPS6KB1 | P23443 | 1/20 | 0.35 |
| ▸ | AXL | P30530 | 1/20 | 0.35 |
| ▸ | AKT2 | P31751 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25786203 | 0.94 | BAD (0.41) | BADBCL2L1BCL2MCL1PMAIP1 | |
| SCHEMBL25786215 | 0.89 | BAD (0.40) | BADBCL2L1BCL2MCL1PMAIP1 | |
| SCHEMBL25786214 | 0.88 | BAD (0.40) | BADBCL2L1BCL2MCL1PMAIP1 | |
| SCHEMBL25251696 | 0.87 | KMT2A (0.35) | BADBCL2L1BCL2MCL1PMAIP1 | |
| SCHEMBL29897078 | 0.87 | KMT2A (0.35) | BADBCL2L1BCL2MCL1PMAIP1 | |
| SCHEMBL25786210 | 0.86 | BAD (0.36) | BADBCL2L1BCL2MCL1PMAIP1 | |
| SCHEMBL25786165 | 0.86 | BAD (0.43) | BADBCL2L1BCL2MCL1 | |
| SCHEMBL25786224 | 0.85 | BAD (0.43) | BADBCL2L1BCL2MCL1PMAIP1 | |
| SCHEMBL25786206 | 0.85 | BAD (0.35) | BADBCL2L1BCL2MCL1PMAIP1 | |
| SCHEMBL25786216 | 0.84 | BAD (0.38) | BADBCL2L1BCL2MCL1PMAIP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11691989-B2 | Macrocyclic indoles as Mcl-1 inhibitors | ASCENTAGE PHARMA (SUZHOU) CO., LTD. (CN) | 2023-07-04 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11691989-B2 | Macrocyclic indoles as Mcl-1 inhibitors | MCL1, BCL2A1, BCL2L1 | BAD 20/4885BCL2L1 3/4885BCL2 10/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.