Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC6 | Q9UBN7 | 4/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 4/20 | 0.39 |
| ▸ | RAB9A | P51151 | 3/20 | 0.39 |
| ▸ | FLT1 | P17948 | 3/20 | 0.38 |
| ▸ | KDR | P35968 | 3/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.37 |
| ▸ | MAPT | P10636 | 2/20 | 0.37 |
| ▸ | ABCG2 | Q9UNQ0 | 3/20 | 0.37 |
| ▸ | HPGD | P15428 | 3/20 | 0.36 |
| ▸ | NPC1 | O15118 | 2/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.36 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.36 |
| ▸ | KIT | P10721 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.36 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.36 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21749297 | 0.93 | HDAC6 (0.47) | HDAC6L3MBTL1RAB9AFLT1KDR | |
| SCHEMBL25786602 | 0.89 | CYP3A4 (0.40) | HDAC6CYP3A4CYP2C19L3MBTL1RAB9A | |
| SCHEMBL21749272 | 0.85 | FLT1 (0.47) | L3MBTL1RAB9AFLT1KDRSMN1; SMN2 | |
| SCHEMBL25786690 | 0.83 | FLT1 (0.40) | L3MBTL1RAB9AFLT1KDRSMN1; SMN2 | |
| SCHEMBL21749247 | 0.83 | HIF1A (0.45) | HDAC6CYP3A4CYP2C19L3MBTL1RAB9A | |
| SCHEMBL25787692 | 0.82 | CYP3A4 (0.39) | HDAC6CYP3A4CYP2C19L3MBTL1RAB9A | |
| SCHEMBL25787689 | 0.79 | HIF1A (0.38) | HDAC6CYP3A4CYP2C19L3MBTL1RAB9A | |
| SCHEMBL25786687 | 0.79 | SMN1; SMN2 (0.47) | HDAC6CYP3A4CYP2C19L3MBTL1RAB9A | |
| SCHEMBL20552643 | 0.78 | ABCG2 (0.47) | HDAC6SMN1; SMN2MAPTABCG2ALDH1A1 | |
| SCHEMBL21749304 | 0.78 | NPC1 (0.46) | HDAC6RAB9ASMN1; SMN2ABCG2NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230192607-A1 | TRANSCRIPTIONAL ENHANCED ASSOCIATE DOMAIN (TEAD) TRANSCRIPTION FACTOR INHIBITORS AND USES THEREOF | DANA-FARBER CANCER INSTITUTE, INC. (US) | 2023-06-22 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230192607-A1 | TRANSCRIPTIONAL ENHANCED ASSOCIATE DOMAIN (TEAD) TRANSCRIPTION FACTOR INHIBITORS AND USES THEREOF | TEAD1, TEAD4, TEAD2 | HDAC6 921/4885CYP3A4 1995/4885CYP2C19 4704/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.