Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH4 | Q9H3N8 | 11/20 | 0.78 |
| ▸ | HRH3 | Q9Y5N1 | 3/20 | 0.61 |
| ▸ | GPR183 | P32249 | 5/20 | 0.61 |
| ▸ | NPC1 | O15118 | 2/20 | 0.53 |
| ▸ | RAB9A | P51151 | 2/20 | 0.53 |
| ▸ | POLB | P06746 | 2/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.51 |
| ▸ | MEN1 | O00255 | 1/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6130840 | 0.87 | HRH4 (1.00) | HRH4HRH3NPC1RAB9A | |
| SCHEMBL16598933 | 0.87 | HRH4 (0.76) | HRH4HRH3GPR183NPC1RAB9A | |
| SCHEMBL377743 | 0.85 | HRH4 (0.78) | HRH4HRH3GPR183NPC1RAB9A | |
| SCHEMBL20618075 | 0.82 | HRH4 (0.64) | HRH4HRH3GPR183POLBMEN1 | |
| SCHEMBL26490234 | 0.82 | HRH4 (0.68) | HRH4HRH3GPR183NPC1RAB9A | |
| SCHEMBL16598725 | 0.80 | HRH4 (0.65) | HRH4HRH3GPR183POLBSMN1; SMN2 | |
| SCHEMBL26074492 | 0.80 | HRH4 (0.65) | HRH4HRH3GPR183POLBMEN1 | |
| SCHEMBL12334085 | 0.79 | NPC1 (0.77) | HRH4HRH3NPC1RAB9AMEN1 | |
| SCHEMBL17938753 | 0.79 | GPR183 (0.67) | HRH4HRH3GPR183NPC1RAB9A | |
| SCHEMBL16306806 | 0.78 | GPR183 (0.64) | HRH4HRH3GPR183NPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4206197-A1 | PREPARATION METHOD FOR NOVEL RHO-RELATED PROTEIN KINASE INHIBITOR AND INTERMEDIATE IN PREPARATION METHOD | Beijing Tide Pharmaceutical Co., Ltd. (CN) | 2023-07-05 | — | — | EP | disclosed |