Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRKDC | P78527 | 2/20 | 0.38 |
| ▸ | KIF11 | P52732 | 1/20 | 0.38 |
| ▸ | CDK1 | P06493 | 1/20 | 0.38 |
| ▸ | CDK2 | P24941 | 1/20 | 0.38 |
| ▸ | ADRB3 | P13945 | 5/20 | 0.38 |
| ▸ | ADRB1 | P08588 | 4/20 | 0.38 |
| ▸ | ADRB2 | P07550 | 3/20 | 0.37 |
| ▸ | BTK | Q06187 | 2/20 | 0.37 |
| ▸ | ACLY | P53396 | 1/20 | 0.37 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.37 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.37 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.37 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.37 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.37 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.36 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.36 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 2/20 | 0.35 |
| ▸ | PKM | P14618 | 1/20 | 0.35 |
| ▸ | PSMD14 | O00487 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25796194 | 0.85 | BTK (0.42) | ADRB3ADRB1ADRB2BTKPIK3CA | |
| SCHEMBL25795912 | 0.84 | BTK (0.38) | PRKDCBTKMCL1MAPTEGFR | |
| SCHEMBL30549624 | 0.84 | BTK (0.38) | PRKDCBTKMCL1MAPTEGFR | |
| SCHEMBL30549742 | 0.83 | TRPV1 (0.41) | MAPT | |
| SCHEMBL25795808 | 0.83 | KCNH2 (0.44) | BTKMAPK14MAPT | |
| SCHEMBL25796278 | 0.82 | BTK (0.38) | ADRB3ADRB1ADRB2BTKLRRK2 | |
| SCHEMBL25795650 | 0.81 | HRH3 (0.41) | ADRB3ACLYMCL1 | |
| SCHEMBL25797450 | 0.81 | AOC3 (0.43) | ADRB3MCL1PKM | |
| SCHEMBL30550018 | 0.81 | HRH3 (0.41) | ADRB3ACLYMCL1 | |
| SCHEMBL30549782 | 0.81 | BACE1 (0.38) | ADRB3PIK3CDPKM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023109912-A1 | 3, 4-DIHYDROISOQUINOLIN-1 (2H) -ONES DERIVATIVES AS STING ANTAGONISTS AND THE USE THEREOF | BEIGENE, LTD. (KY) | 2023-06-22 | — | — | WO | disclosed |