Known targets — ChEMBL curated mechanism
CHRM1DRD2DRD3DRD4HDAC1HDAC10HDAC11HDAC2HDAC3HDAC4HDAC5HDAC6HDAC7HDAC8HDAC9HRH1HTR2APDE3ASIGMAR1SLC9A3
The experimentally established mechanism targets of L-Lactic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TP53 | P04637 | 2/20 | 0.40 |
| ▸ | CA5A | P35218 | 1/20 | 0.35 |
| ▸ | CA5B | Q9Y2D0 | 1/20 | 0.35 |
| ▸ | CA4 | P22748 | 2/20 | 0.32 |
| ▸ | CA2 | P00918 | 1/20 | 0.32 |
| ▸ | CA1 | P00915 | 5/20 | 0.32 |
| ▸ | TSHR | P16473 | 2/20 | 0.31 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.31 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.31 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.31 |
| ▸ | MEN1 | O00255 | 1/20 | 0.30 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.30 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| L-Lactic Acid SCHEMBL27674550 | 1.00 | TP53 (0.40) | TP53CA5ACA5BCA4CA2 | |
| L-Lactic Acid SCHEMBL28286518 | 0.94 | TP53 (0.40) | TP53CA5ACA5BCA4CA2 | |
| L-Lactic Acid SCHEMBL6394826 | 0.88 | TP53 (0.40) | TP53CA4CA2CA1TSHR | |
| L-Lactic Acid SCHEMBL3446641 | 0.88 | TP53 (0.40) | TP53CA4CA2CA1TSHR | |
| L-Lactic Acid SCHEMBL2419423 | 0.87 | TP53 (0.50) | TP53CA4CA2CA1TSHR | |
| L-Lactic Acid SCHEMBL29683322 | 0.87 | TP53 (0.50) | TP53CA4CA2CA1TSHR | |
| L-Lactic Acid SCHEMBL1532627 | 0.87 | TP53 (0.50) | TP53CA4CA2CA1TSHR | |
| L-Lactic Acid SCHEMBL29351424 | 0.87 | TP53 (0.50) | TP53CA4CA2CA1TSHR | |
| L-Lactic Acid SCHEMBL4319 | 0.87 | TP53 (0.50) | TP53CA4CA2CA1TSHR | |
| L-Lactic Acid SCHEMBL4648043 | 0.87 | TP53 (0.50) | TP53CA4CA2CA1TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-108129290-A | A kind of method of sulfate radical in removal lactic acid | 武汉三江航天固德生物科技有限公司 | 2018-06-08 | — | — | CN | disclosed |
| CN-102864105-B | Method for producing L-lactic acid and Exiguobacterium aurantiacum special for method | CHINESE ACAD INST MICROBIOLOGY | 2013-10-23 | — | — | CN | disclosed |
| CN-103194402-A | L-lactic acid production method and special Bacillus sp. therefor | CHINESE ACAD INST MICROBIOLOGY | 2013-07-10 | — | — | CN | disclosed |
| CN-102864105-A | Method for producing L-lactic acid and Exiguobacterium aurantiacum special for method | CHINESE ACAD INST MICROBIOLOGY | 2013-01-09 | — | — | CN | disclosed |
| US-20120112127-A1 | RECOVERY OF ORGANIC ACIDS | ZEACHEM, INC. (US) | 2012-05-10 | — | — | US | disclosed |
| US-8048655-B2 | Recovery of organic acids | ZEACHEM, INC. (US) | 2011-11-01 | — | — | US | disclosed |
| CN-102050723-A | Method for producing sodium lactate | CHINA PETROLEUM & CHEMICAL | 2011-05-11 | — | — | CN | disclosed |
| US-20100187472-A1 | RECOVERY OF ORGANIC ACIDS | ZEACHEM, INC. (US) | 2010-07-29 | — | — | US | disclosed |
| US-7601865-B2 | Introducing tertiary amine and CO2 to dilute salt solution to form acid/amine complex and insoluble carbonate salt, introducing water immiscible solvent to dilute salt solution to form reaction phase, continuously drying reaction phase and forming product | ZEACHEM, INC. (US) | 2009-10-13 | — | — | US | disclosed |
| US-20050256337-A1 | Introducing tertiary amine and CO2 to dilute salt solution to form acid/amine complex and insoluble carbonate salt, introducing water immiscible solvent to dilute salt solution to form reaction phase, continuously drying reaction phase and forming product | ZEACHEM INC. (US) | 2005-11-17 | — | — | US | disclosed |