Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDK4 | Q16654 | 1/20 | 0.49 |
| ▸ | GRM1 | Q13255 | 10/20 | 0.43 |
| ▸ | GRM5 | P41594 | 9/20 | 0.43 |
| ▸ | HTR6 | P50406 | 1/20 | 0.42 |
| ▸ | JAK1 | P23458 | 1/20 | 0.41 |
| ▸ | CNR1 | P21554 | 1/20 | 0.40 |
| ▸ | NAMPT | P43490 | 1/20 | 0.40 |
| ▸ | GABRP | O00591 | 1/20 | 0.40 |
| ▸ | GABRD | O14764 | 1/20 | 0.40 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.40 |
| ▸ | GABRB1 | P18505 | 1/20 | 0.40 |
| ▸ | GABRG2 | P18507 | 1/20 | 0.40 |
| ▸ | GABRB3 | P28472 | 1/20 | 0.40 |
| ▸ | GABRA5 | P31644 | 1/20 | 0.40 |
| ▸ | GABRA3 | P34903 | 1/20 | 0.40 |
| ▸ | GABRA2 | P47869 | 1/20 | 0.40 |
| ▸ | GABRB2 | P47870 | 1/20 | 0.40 |
| ▸ | GABRA4 | P48169 | 1/20 | 0.40 |
| ▸ | GABRE | P78334 | 1/20 | 0.40 |
| ▸ | GABRA6 | Q16445 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25817261 | 0.81 | PDK4 (0.54) | PDK4GRM1GRM5HTR6JAK1 | |
| SCHEMBL25817295 | 0.80 | PDK4 (0.53) | PDK4GRM1GRM5HTR6JAK1 | |
| SCHEMBL25817275 | 0.77 | PDK4 (0.50) | PDK4GRM1GRM5HTR6JAK1 | |
| SCHEMBL21871400 | 0.76 | PDK4 (0.52) | PDK4GRM1GRM5HTR6JAK1 | |
| SCHEMBL23210198 | 0.75 | PDK4 (0.63) | PDK4GRM1GRM5HTR6JAK1 | |
| SCHEMBL14270840 | 0.74 | PDK4 (0.54) | PDK4GRM1GRM5HTR6JAK1 | |
| SCHEMBL20112166 | 0.74 | PDK4 (0.58) | PDK4GRM1GRM5HTR6JAK1 | |
| SCHEMBL19703159 | 0.73 | PDK4 (0.55) | PDK4GRM1GRM5HTR6JAK1 | |
| SCHEMBL21855632 | 0.73 | PDK4 (0.67) | PDK4GRM1GRM5HTR6JAK1 | |
| SCHEMBL31150581 | 0.73 | PDK4 (0.67) | PDK4GRM1GRM5HTR6JAK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230212139-A1 | 2-AZASPIRO[3.4]OCTANE DERIVATIVES AS M4 AGONISTS | NOVARTIS INSTITUTES FOR BIOMEDICAL RESEARCH, INC. | 2023-07-06 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230212139-A1 | 2-AZASPIRO[3.4]OCTANE DERIVATIVES AS M4 AGONISTS | CHRM2, CHRM1, CHRM3 | PDK4 4021/4885GRM1 121/4885GRM5 241/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.