Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NTRK1 | P04629 | 13/20 | 1.00 |
| ▸ | NTRK3 | Q16288 | 2/20 | 0.79 |
| ▸ | NTRK2 | Q16620 | 2/20 | 0.79 |
| ▸ | GRK6 | P43250 | 1/20 | 0.68 |
| ▸ | DYRK3 | O43781 | 1/20 | 0.65 |
| ▸ | JAK2 | O60674 | 1/20 | 0.65 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.65 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.65 |
| ▸ | PAK4 | O96013 | 1/20 | 0.65 |
| ▸ | ABL1 | P00519 | 1/20 | 0.65 |
| ▸ | LCK | P06239 | 1/20 | 0.65 |
| ▸ | FYN | P06241 | 1/20 | 0.65 |
| ▸ | CSF1R | P07333 | 1/20 | 0.65 |
| ▸ | RET | P07949 | 1/20 | 0.65 |
| ▸ | IGF1R | P08069 | 1/20 | 0.65 |
| ▸ | MET | P08581 | 1/20 | 0.65 |
| ▸ | ROS1 | P08922 | 1/20 | 0.65 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.65 |
| ▸ | PRKACA | P17612 | 1/20 | 0.65 |
| ▸ | FLT1 | P17948 | 1/20 | 0.65 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22034770 | 0.94 | NTRK1 (0.88) | NTRK1NTRK3NTRK2DYRK3JAK2 | |
| SCHEMBL31471730 | 0.88 | NTRK1 (0.79) | NTRK1NTRK3NTRK2DYRK3JAK2 | |
| SCHEMBL25819015 | 0.88 | NTRK1 (1.00) | NTRK1NTRK3NTRK2CYP1A2CYP2D6 | |
| SCHEMBL31471757 | 0.88 | NTRK1 (0.79) | NTRK1NTRK3NTRK2GRK6DYRK3 | |
| SCHEMBL12430677 | 0.86 | NTRK1 (0.75) | NTRK1NTRK3NTRK2GRK6DYRK3 | |
| SCHEMBL31471785 | 0.86 | NTRK1 (0.75) | NTRK1NTRK3NTRK2GRK6DYRK3 | |
| SCHEMBL31471720 | 0.85 | NTRK1 (0.73) | NTRK1NTRK3NTRK2GRK6ULK1 | |
| SCHEMBL12430691 | 0.85 | NTRK1 (0.74) | NTRK1NTRK3NTRK2DYRK3JAK2 | |
| SCHEMBL12430704 | 0.84 | NTRK1 (0.72) | NTRK1NTRK3NTRK2GRK6DYRK3 | |
| Hydrochloric Acid SCHEMBL31471731 | 0.84 | NTRK1 (0.72) | NTRK1NTRK3NTRK2DYRK3JAK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023123883-A1 | METHOD FOR PREPARING QUINAZOLINE DERIVATIVE AND ANALOG THEREOF AND USE THEREOF | 沈阳药科大学 | 2023-07-06 | — | — | WO | disclosed |