Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LATS1 | O95835 | 1/20 | 0.38 |
| ▸ | LRRK2 | Q5S007 | 5/20 | 0.36 |
| ▸ | SYK | P43405 | 1/20 | 0.36 |
| ▸ | MAP3K7 | O43318 | 1/20 | 0.34 |
| ▸ | BACE1 | P56817 | 1/20 | 0.34 |
| ▸ | PRKDC | P78527 | 2/20 | 0.33 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.33 |
| ▸ | IDH1 | O75874 | 1/20 | 0.33 |
| ▸ | CLK1 | P49759 | 1/20 | 0.33 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.33 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.33 |
| ▸ | MTOR | P42345 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | GLA | P06280 | 1/20 | 0.32 |
| ▸ | GAA | P10253 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
| ▸ | MAP3K12 | Q12852 | 1/20 | 0.32 |
| ▸ | FFAR2 | O15552 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
| ▸ | GSK3B | P49841 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25820105 | 0.84 | CLK1 (0.44) | LRRK2PRKDCCLK1DYRK1APIK3CA | |
| SCHEMBL25820146 | 0.84 | LATS1 (0.37) | LATS1SYKMAP3K7BACE1PRKDC | |
| SCHEMBL25820119 | 0.81 | F2RL1 (0.35) | LRRK2IDH1MEN1GLAGAA | |
| SCHEMBL25820116 | 0.80 | MEN1 (0.34) | LRRK2CLK1DYRK1AMEN1GLA | |
| SCHEMBL25821153 | 0.80 | PRKDC (0.43) | LRRK2PRKDCCLK1DYRK1AMEN1 | |
| SCHEMBL25820106 | 0.80 | IP6K1 (0.45) | MEN1GLAGAAKMT2AMAPT | |
| SCHEMBL25820104 | 0.80 | IP6K1 (0.48) | MEN1GLAGAAKMT2AMAPT | |
| SCHEMBL26317997 | 0.80 | GAK (0.43) | LATS1LRRK2SYKMAP3K7BACE1 | |
| SCHEMBL25820121 | 0.79 | MAP4K4 (0.49) | PRKDCMEN1GLAGAAKMT2A | |
| SCHEMBL25820120 | 0.78 | MEN1 (0.38) | CLK1DYRK1AMEN1GLAGAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230219927-A1 | AKT3 MODULATORS | Georgiamune Inc. | 2023-07-13 | — | — | US | disclosed |
| US-20230183226-A1 | AKT3 MODULATORS | Georgiamune Inc. | 2023-06-15 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230183226-A1 | AKT3 MODULATORS | AKT3, AKT2, MTOR | LATS1 764/4885LRRK2 500/4885SYK 1886/4885 |
| US-20230219927-A1 | AKT3 MODULATORS | AKT3, AKT2, PIK3CA | LATS1 1192/4885LRRK2 820/4885SYK 1923/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.