Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | WEE1 | P30291 | 20/20 | 0.80 |
| ▸ | PLK1 | P53350 | 4/20 | 0.74 |
| ▸ | GAK | O14976 | 1/20 | 0.74 |
| ▸ | EPHB6 | O15197 | 1/20 | 0.74 |
| ▸ | JAK2 | O60674 | 1/20 | 0.74 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.74 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.74 |
| ▸ | PAK4 | O96013 | 1/20 | 0.74 |
| ▸ | ABL1 | P00519 | 1/20 | 0.74 |
| ▸ | LCK | P06239 | 1/20 | 0.74 |
| ▸ | FYN | P06241 | 1/20 | 0.74 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.74 |
| ▸ | WEE2 | P0C1S8 | 1/20 | 0.74 |
| ▸ | BCR | P11274 | 1/20 | 0.74 |
| ▸ | CSNK2A2 | P19784 | 1/20 | 0.74 |
| ▸ | SYK | P43405 | 1/20 | 0.74 |
| ▸ | CSNK1A1 | P48729 | 1/20 | 0.74 |
| ▸ | NEK2 | P51955 | 1/20 | 0.74 |
| ▸ | NEK3 | P51956 | 1/20 | 0.74 |
| ▸ | JAK3 | P52333 | 1/20 | 0.74 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30604492 | 0.99 | WEE1 (0.79) | WEE1PLK1GAKEPHB6JAK2 | |
| SCHEMBL30604490 | 0.99 | WEE1 (0.79) | WEE1PLK1GAKEPHB6JAK2 | |
| SCHEMBL26115790 | 0.97 | WEE1 (0.82) | WEE1PLK1GAKEPHB6JAK2 | |
| SCHEMBL25585758 | 0.97 | WEE1 (0.80) | WEE1PLK1GAKEPHB6JAK2 | |
| SCHEMBL26120918 | 0.97 | WEE1 (0.77) | WEE1PLK1GAKEPHB6JAK2 | |
| SCHEMBL25826225 | 0.96 | WEE1 (0.75) | WEE1PLK1GAKEPHB6JAK2 | |
| SCHEMBL26121242 | 0.94 | WEE1 (0.79) | WEE1PLK1GAKEPHB6JAK2 | |
| SCHEMBL30604484 | 0.94 | WEE1 (0.80) | WEE1PLK1GAKEPHB6JAK2 | |
| SCHEMBL30604489 | 0.94 | WEE1 (0.80) | WEE1PLK1GAKEPHB6JAK2 | |
| SCHEMBL24257335 | 0.94 | WEE1 (0.91) | WEE1PLK1GAKEPHB6JAK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023193789-A1 | WEE1 DEGRADING COMPOUNDS | BEIJING NEOX BIOTECH LIMITED (CN) | 2023-10-12 | — | — | WO | disclosed |
| WO-2023125944-A1 | COMPOUND CONTAINING HETEROCYCLIC RING | 正大天晴药业集团股份有限公司 | 2023-07-06 | — | — | WO | disclosed |